中文
English
한국어
日本語
Español
Français
Русский
| カタログ番号 | HF797014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 種反応性 | Human, Mouse | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human LRP5 (Cys1332-Leu1397). | ||||||||
| ターゲット | Low-density lipoprotein receptor-related protein 5, LRP5, LRP-5, LRP7, LRP-7, Low-density lipoprotein receptor-related protein 7, LR3 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | O75197 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
||||||||
| 製品使用情報 |
| ||||||||
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Low-density lipoprotein receptor-related protein 5 (LRP5) is a ~179 kDa protein. Acts as a coreceptor with members of the frizzled family of seven-transmembrane spanning receptors to transduce signal by Wnt proteins. Activates the canonical Wnt signaling pathway that controls cell fate determination and self-renewal during embryonic development and adult tissue regeneration. In particular, may play an important role in the development of the posterior patterning of the epiblast during gastrulation. During bone development, regulates osteoblast proliferation and differentiation thus determining bone mass. Mechanistically, the formation of the signaling complex between Wnt ligand, frizzled receptor and LRP5 coreceptor promotes the recruitment of AXIN1 to LRP5, stabilizing beta-catenin/CTNNB1 and activating TCF/LEF-mediated transcriptional programs. 1. Mao, J. et al. (2001) Molecular cell 7, 801-9. PMID: 11336703 2. Semënov, MV. et al. (2001) Current biology : CB 11, 951-61. PMID: 11448771 3. Gong, Y. et al. (2001) Cell 107, 513-23. PMID: 11719191 4. Li, X. et al. (2005) The Journal of biological chemistry 280, 19883-7. PMID: 15778503 5. Semënov, M. et al. (2005) The Journal of biological chemistry 280, 26770-5. PMID: 15908424 6. Ai, M. et al. (2005) American journal of human genetics 77, 741-53. PMID: 16252235 | ||||||||
| 注意事項 | For research use only. |
+86-027-65523339
中国武漢市深敦寺路666号C棟、武漢、430206
