Anti-Mouse TACE/ADAM17 Recombinant Antibody (A12), PE (MX200127)

Name: Anti-Mouse TACE/ADAM17 Recombinant Antibody (A12), PE
Brand: abinScience
SKU: MX200127
Price: 290 USD
Availability: InStock

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Número de catálogo	MX200127
Reactividad de especies	Human, Mouse
Aplicaciones	ELISA, FCM
Especie huésped	Rat
Clonalidad	Monoclonal
Isotipo	IgG1, kappa
ID de clon	A12
Conjugación	PE
Objetivo	Disintegrin and metalloproteinase domain-containing protein 17, ADAM 17, TNF-alpha convertase, TNF-alpha-converting enzyme, CD156b, Adam17, Tace
Nivel de endotoxinas	Please contact with the lab for this information.
Productos asociados	Rat IgG1, kappa Recombinant Isotype Control Antibody (ES26-14D1.11), PE
Número de acceso	Q9Z0F8
Forma	Liquid
Buffer de almacenamiento	0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300. Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Estabilidad y almacenamiento	Store at 4°C for 12 months. Protect from light. Do not freeze.
Fondo	Disintegrin and metalloproteinase domain-containing protein 17 (CD156b/ADAM17) is a ~93 kDa protein. Cleaves the membrane-bound precursor of TNF to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Plays a role in the proteolytic processing of ACE2. Responsible for the proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1 and the amyloid precursor protein. Acts as an activator of Notch pathway by mediating cleavage of Notch, generating the membrane-associated intermediate fragment called notch extracellular truncation (NEXT). 1. Reddy, P. et al. (2000) The Journal of biological chemistry 275, 14608-14. PMID: 10799547 2. Zhang, Y. et al. (2000) Endocrinology 141, 4342-8. PMID: 11108241 3. Brou, C. et al. (2000) Molecular cell 5, 207-16. PMID: 10882063 4. Bergmeier, W. et al. (2003) Blood 102, 4229-35. PMID: 12907434 5. Li, N. et al. (2007) The EMBO journal 26, 494-504. PMID: 17245433
Nota	For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only.

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Anti-Mouse TACE/ADAM17 Recombinant Antibody (A12), PE.pdf

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