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| カタログ番号 | MX200147 |
|---|---|
| 種反応性 | Human, Mouse |
| アプリケーション | ELISA, FCM |
| 宿主種 | Rat |
| クローン性 | Monoclonal |
| アイソタイプ | IgG1, kappa |
| クローンID | A12 |
| 抱合 | PerCP |
| ターゲット | Disintegrin and metalloproteinase domain-containing protein 17, ADAM 17, TNF-alpha convertase, TNF-alpha-converting enzyme, CD156b, Adam17, Tace |
| エンドトキシンレベル | Please contact with the lab for this information. |
| 関連製品 | Rat IgG1, kappa Recombinant Isotype Control Antibody (ES26-14D1.11), PerCP |
| アクセッション番号 | Q9Z0F8 |
| 形態 | Liquid |
| 保存バッファー | 0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
| 安定性と保存 | Store at 4°C for 12 months. Protect from light. Do not freeze. |
| 背景 | Disintegrin and metalloproteinase domain-containing protein 17 (CD156b/ADAM17) is a ~93 kDa protein. Cleaves the membrane-bound precursor of TNF to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Plays a role in the proteolytic processing of ACE2. Responsible for the proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1 and the amyloid precursor protein. Acts as an activator of Notch pathway by mediating cleavage of Notch, generating the membrane-associated intermediate fragment called notch extracellular truncation (NEXT). 1. Reddy, P. et al. (2000) The Journal of biological chemistry 275, 14608-14. PMID: 10799547 2. Zhang, Y. et al. (2000) Endocrinology 141, 4342-8. PMID: 11108241 3. Brou, C. et al. (2000) Molecular cell 5, 207-16. PMID: 10882063 4. Bergmeier, W. et al. (2003) Blood 102, 4229-35. PMID: 12907434 5. Li, N. et al. (2007) The EMBO journal 26, 494-504. PMID: 17245433 |
| 注意事項 | For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only. |
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