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| カタログ番号 | MB123014 | ||||||||
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| 説明 |
Anti-Mouse NKG2D/CD314 Polyclonal Antibody (MB123014) is a rabbit polyclonal antibody detecting NKG2D/CD314 in ELISA, IHC, WB. Suitable for Mouse.
Highlights
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| 種反応性 | Mouse | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Mouse CD314/KLRK1/NKG2D (Phe90-Val232). | ||||||||
| ターゲット | KLRK1, NKG2D, Killer cell lectin-like receptor subfamily K member 1, NKG2-D-activating NK receptor, D12S2489E, NKG2-D type II integral membrane protein, NK cell receptor D, CD314 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | O54709 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | NKG2-D type II integral membrane protein (CD314/KLRK1) is a ~26 kDa protein. Functions as an activating and costimulatory receptor involved in immunosurveillance upon binding to various cellular stress-inducible ligands displayed at the surface of autologous tumor cells and virus-infected cells. Provides both stimulatory and costimulatory innate immune responses on activated killer (NK) cells, leading to cytotoxic activity. Acts as a costimulatory receptor for T-cell receptor (TCR) in CD8(+) T-cell-mediated adaptive immune responses by amplifying T-cell activation. Stimulates perforin-mediated elimination of ligand-expressing tumor cells. Signaling involves calcium influx, culminating in the expression of TNF. | ||||||||
| 注意事項 | For research use only. |
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