Anti-Mouse CD5 Recombinant Antibody (SAA2084) (MY046023)

Name: Anti-Mouse CD5 Recombinant Antibody (SAA2084)
Brand: abinScience
SKU: MY046023
Price: 110 USD
Availability: InStock

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Цена(USD):

Спецификация:

20ug
50ug
100ug
1mg

Количество:

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Обзор
Изображения
Ссылки
Даташит
SDS

Обзор

Каталожный номер

MY046023

Реактивность видов

Mouse

Применения

ELISA

Хозяинский вид

Human

Клоональность

Monoclonal

Изотип

VHH-hFc

ID клона

SAA2084

Цель

Lyt-1, Cd5, CD5, T-cell surface glycoprotein CD5, Ly-1, Lymphocyte antigen 1

Уровень эндотоксинов

Please contact with the lab for this information.

Чистота

>95% as determined by SDS-PAGE.

Очистка

Protein A/G purified from cell culture supernatant.

Номер доступа

P13379

RRID

Anti-Mouse CD5/Ly-1 Antibody (SAA2084) (abinScience Cat# MY046023, RRID:AB_3729344)

Форма

Liquid

Буфер хранения

0.01M PBS pH 7.4

Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.

Информация об использовании продукта

Применение	Разбавление
ELISA	1:2000-1:20000

Устойчивость и хранение

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Фон

T-cell surface glycoprotein CD5 (Ly-1) is a ~53 kDa protein. Lymphoid-specific receptor expressed by all T-cells and in a subset of B-cells known as B1a cells. Plays a role in the regulation of TCR and BCR signaling, thymocyte selection, T-cell effector differentiation and immune tolerance. Acts by interacting with several ligands expressed on B-cells such as CD5L or CD72 and thereby plays an important role in contact-mediated, T-dependent B-cell activation and in the maintenance of regulatory T and B-cell homeostasis. Functions as a negative regulator of TCR signaling during thymocyte development by associating with several signaling proteins including LCK, CD3Z chain, PI3K or CBL. Mechanistically, co-engagement of CD3 with CD5 enhances phosphorylated CBL recruitment leading to increased VAV1 phosphorylation and degradation.

1. Schuster, C. et al. (2022) Frontiers in immunology 13, 906499. PMID: 35720357

2. Zheng, M. et al. (2014) Immunological investigations 43, 705-16. PMID: 24950378

3. Biancone, L. et al. (1996) The Journal of experimental medicine 184, 811-9. PMID: 9064341

4. Bikah, G. et al. (1998) International immunology 10, 1185-96. PMID: 9723705

5. Dennehy, KM. et al. (2001) International immunology 13, 149-56. PMID: 11157848

Примечание

For research use only.

Isotype Control

Human IgG1 Recombinant Isotype Control Antibody (HyHEL-10) (HV080407)
Human IgG1 Recombinant Isotype Control Antibody (13R4) (HV080507)

Изображения