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| カタログ番号 | MY046033 | ||||
|---|---|---|---|---|---|
| 種反応性 | Mouse | ||||
| アプリケーション | ELISA | ||||
| 宿主種 | Human | ||||
| クローン性 | Monoclonal | ||||
| アイソタイプ | VHH-hFc | ||||
| クローンID | SAA2085 | ||||
| ターゲット | Lyt-1, Cd5, CD5, T-cell surface glycoprotein CD5, Ly-1, Lymphocyte antigen 1 | ||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||
| 純度 | >95% as determined by SDS-PAGE. | ||||
| 精製 | Protein A/G purified from cell culture supernatant. | ||||
| アクセッション番号 | P13379 | ||||
| RRID | Anti-Mouse CD5/Ly-1 Antibody (SAA2085) (abinScience Cat# MY046033, RRID:AB_3729345) |
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| 形態 | Liquid | ||||
| 保存バッファー | 0.01M PBS pH 7.4 データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term. | ||||
| 背景 | T-cell surface glycoprotein CD5 (Ly-1) is a ~53 kDa protein. Lymphoid-specific receptor expressed by all T-cells and in a subset of B-cells known as B1a cells. Plays a role in the regulation of TCR and BCR signaling, thymocyte selection, T-cell effector differentiation and immune tolerance. Acts by interacting with several ligands expressed on B-cells such as CD5L or CD72 and thereby plays an important role in contact-mediated, T-dependent B-cell activation and in the maintenance of regulatory T and B-cell homeostasis. Functions as a negative regulator of TCR signaling during thymocyte development by associating with several signaling proteins including LCK, CD3Z chain, PI3K or CBL. Mechanistically, co-engagement of CD3 with CD5 enhances phosphorylated CBL recruitment leading to increased VAV1 phosphorylation and degradation. 1. Schuster, C. et al. (2022) Frontiers in immunology 13, 906499. PMID: 35720357 2. Zheng, M. et al. (2014) Immunological investigations 43, 705-16. PMID: 24950378 3. Biancone, L. et al. (1996) The Journal of experimental medicine 184, 811-9. PMID: 9064341 4. Bikah, G. et al. (1998) International immunology 10, 1185-96. PMID: 9723705 5. Dennehy, KM. et al. (2001) International immunology 13, 149-56. PMID: 11157848 | ||||
| 注意事項 | For research use only. | ||||
| Isotype Control | Human IgG1 Recombinant Isotype Control Antibody (HyHEL-10) (HV080407) Human IgG1 Recombinant Isotype Control Antibody (13R4) (HV080507) |
Detects Recombinant Mouse CD5 Protein, C-His (Cat No.: MY046011) in indirect ELISA.
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