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| カタログ番号 | MF909033 | ||||
|---|---|---|---|---|---|
| 説明 |
Anti-Mouse Beta-NGF Recombinant Antibody (alphaD11) (MF909033) is a mouse monoclonal antibody detecting beta-NGF in ELISA, FCM. Suitable for Mouse, Rat.
Highlights
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| 種反応性 | Mouse, Rat | ||||
| アプリケーション | ELISA, FCM | ||||
| 宿主種 | Mouse | ||||
| クローン性 | Monoclonal | ||||
| アイソタイプ | IgG2a, kappa | ||||
| クローンID | alphaD11 | ||||
| ターゲット | Beta-NGF, Beta-nerve growth factor, NGF, NGFB | ||||
| エンドトキシンレベル | < 10 EU/mg | ||||
| 純度 | >95% as determined by SDS-PAGE. | ||||
| 精製 | Protein A/G purified from cell culture supernatant. | ||||
| アクセッション番号 | P01139 | ||||
| RRID | Anti-Mouse NGF/Beta-NGF Antibody (alphaD11) (abinScience Cat# MF909033, RRID:AB_3725669) |
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| 形態 | Liquid | ||||
| 保存バッファー | 0.01M PBS pH 7.4. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||
| 背景 | Beta-nerve growth factor (NGF/Beta-NGF) is a ~27 kDa protein. Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades to regulate neuronal proliferation, differentiation and survival. The immature NGF precursor (proNGF) functions as a ligand for the heterodimeric receptor formed by SORCS2 and NGFR, and activates cellular signaling cascades that lead to inactivation of RAC1 and/or RAC2, reorganization of the actin cytoskeleton and neuronal growth cone collapse. In contrast to mature NGF, the precursor form (proNGF) promotes neuronal apoptosis (in vitro). Inhibits metalloproteinase-dependent proteolysis of platelet glycoprotein VI. 1. Feng, D. et al. (2010) Journal of molecular biology 396, 967-84. PMID: 20036257 2. Tong, Q. et al. (2012) FASEB journal : official publication of the Federation of American Societies for Experimental Biology 26, 3811-21. PMID: 22649032 3. Deinhardt, K. et al. (2011) Science signaling 4, ra82. PMID: 22155786 4. Sun, HL. et al. (2015) Acta crystallographica. Section F, Structural biology communications 71, 906-12. PMID: 26144237 | ||||
| 注意事項 | For research use only. | ||||
| Isotype Control | Mouse IgG2a (Fc Silence) Recombinant Isotype Control (MOPC 173) (MF533023) |
SDS-PAGE for Anti-Mouse NGF/Beta-NGF Antibody (alphaD11).
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