Anti-Mouse Beta-NGF Polyclonal Antibody (MF909014)

Name: Anti-Mouse Beta-NGF Polyclonal Antibody
Brand: abinScience
SKU: MF909014
Price: 168 USD
Availability: InStock

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Overview
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References
Datasheet
SDS

Overview

Catalog No.

MF909014

Species reactivity

Mouse, Rat

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Mouse NGF/Beta-NGF (Glu19-Gly241).

Target

Beta-nerve growth factor, NGFB, Beta-NGF, NGF

Purification

Purified by antigen affinity column.

Accession

P01139

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Beta-nerve growth factor (NGF/Beta-NGF) is a ~27 kDa protein. Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades to regulate neuronal proliferation, differentiation and survival. The immature NGF precursor (proNGF) functions as a ligand for the heterodimeric receptor formed by SORCS2 and NGFR, and activates cellular signaling cascades that lead to inactivation of RAC1 and/or RAC2, reorganization of the actin cytoskeleton and neuronal growth cone collapse. In contrast to mature NGF, the precursor form (proNGF) promotes neuronal apoptosis (in vitro). Inhibits metalloproteinase-dependent proteolysis of platelet glycoprotein VI. NGF is the therapeutic target of tanezumab (clinical).

1. Feng, D. et al. (2010) Journal of molecular biology 396, 967-84. PMID: 20036257

2. Tong, Q. et al. (2012) FASEB journal : official publication of the Federation of American Societies for Experimental Biology 26, 3811-21. PMID: 22649032

3. Deinhardt, K. et al. (2011) Science signaling 4, ra82. PMID: 22155786

4. Sun, HL. et al. (2015) Acta crystallographica. Section F, Structural biology communications 71, 906-12. PMID: 26144237

Note

For research use only.

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References

Datasheet