Anti-Mouse Beta-NGF Recombinant Antibody (alphaD11) (MF909033)

Name: Anti-Mouse Beta-NGF Recombinant Antibody (alphaD11)
Brand: abinScience
SKU: MF909033
Price: 110 USD
Availability: InStock

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Спецификация:

20ug
50ug
100ug
1mg

Количество:

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Даташит
SDS

Обзор

Каталожный номер

MF909033

Описание

Anti-Mouse Beta-NGF Recombinant Antibody (alphaD11) (MF909033) is a mouse monoclonal antibody detecting beta-NGF in ELISA, FCM. Suitable for Mouse, Rat.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

Реактивность видов

Mouse, Rat

Применения

ELISA, FCM

Хозяинский вид

Mouse

Клоональность

Monoclonal

Изотип

IgG2a, kappa

ID клона

alphaD11

Цель

Beta-NGF, Beta-nerve growth factor, NGF, NGFB

Уровень эндотоксинов

< 10 EU/mg

Чистота

>95% as determined by SDS-PAGE.

Очистка

Protein A/G purified from cell culture supernatant.

Номер доступа

P01139

RRID

Anti-Mouse NGF/Beta-NGF Antibody (alphaD11) (abinScience Cat# MF909033, RRID:AB_3725669)

Форма

Liquid

Буфер хранения

0.01M PBS pH 7.4.

Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.

Информация об использовании продукта

Применение	Разбавление
ELISA	1:2000-1:20000

Устойчивость и хранение

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Фон

Beta-nerve growth factor (NGF/Beta-NGF) is a ~27 kDa protein. Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades to regulate neuronal proliferation, differentiation and survival. The immature NGF precursor (proNGF) functions as a ligand for the heterodimeric receptor formed by SORCS2 and NGFR, and activates cellular signaling cascades that lead to inactivation of RAC1 and/or RAC2, reorganization of the actin cytoskeleton and neuronal growth cone collapse. In contrast to mature NGF, the precursor form (proNGF) promotes neuronal apoptosis (in vitro). Inhibits metalloproteinase-dependent proteolysis of platelet glycoprotein VI.

1. Feng, D. et al. (2010) Journal of molecular biology 396, 967-84. PMID: 20036257

2. Tong, Q. et al. (2012) FASEB journal : official publication of the Federation of American Societies for Experimental Biology 26, 3811-21. PMID: 22649032

3. Deinhardt, K. et al. (2011) Science signaling 4, ra82. PMID: 22155786

4. Sun, HL. et al. (2015) Acta crystallographica. Section F, Structural biology communications 71, 906-12. PMID: 26144237

Примечание

For research use only.

Isotype Control

Mouse IgG2a (Fc Silence) Recombinant Isotype Control (MOPC 173) (MF533023)

Изображения