Anti-Mouse Beta-NGF Recombinant Antibody (MAb911) (MF909013)

Name: Anti-Mouse Beta-NGF Recombinant Antibody (MAb911)
Brand: abinScience
SKU: MF909013
Price: 110 USD
Availability: InStock

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Especificación:

20ug
50ug
100ug
1mg

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Vista general
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Referencias
Datasheet
SDS

Vista general

Número de catálogo

MF909013

Descripción

Anti-Mouse Beta-NGF Recombinant Antibody (MAb911) (MF909013) is a rat monoclonal antibody detecting beta-NGF in ELISA, FCM, WB. Suitable for Human, Mouse.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

Reactividad de especies

Human, Mouse

Aplicaciones

ELISA, FCM, WB

Especie huésped

Rat

Clonalidad

Monoclonal

Isotipo

IgG1, kappa

ID de clon

MAb911

Objetivo

Beta-NGF, Beta-nerve growth factor, NGF, NGFB

Nivel de endotoxinas

< 10 EU/mg

Pureza

>95% as determined by SDS-PAGE.

Purificación

Protein A/G purified from cell culture supernatant.

Número de acceso

P01139

RRID

Anti-Mouse NGF/Beta-NGF Antibody (MAb911) (abinScience Cat# MF909013, RRID:AB_3725667)

Forma

Liquid

Buffer de almacenamiento

0.01M PBS pH 7.4.

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.

Información de uso del producto

Aplicación	Dilución
ELISA	1:2000-1:20000
WB	1:500-1:2000

Estabilidad y almacenamiento

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Fondo

Beta-nerve growth factor (NGF/Beta-NGF) is a ~27 kDa protein. Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades to regulate neuronal proliferation, differentiation and survival. The immature NGF precursor (proNGF) functions as a ligand for the heterodimeric receptor formed by SORCS2 and NGFR, and activates cellular signaling cascades that lead to inactivation of RAC1 and/or RAC2, reorganization of the actin cytoskeleton and neuronal growth cone collapse. In contrast to mature NGF, the precursor form (proNGF) promotes neuronal apoptosis (in vitro). Inhibits metalloproteinase-dependent proteolysis of platelet glycoprotein VI.

1. Feng, D. et al. (2010) Journal of molecular biology 396, 967-84. PMID: 20036257

2. Tong, Q. et al. (2012) FASEB journal : official publication of the Federation of American Societies for Experimental Biology 26, 3811-21. PMID: 22649032

3. Deinhardt, K. et al. (2011) Science signaling 4, ra82. PMID: 22155786

4. Sun, HL. et al. (2015) Acta crystallographica. Section F, Structural biology communications 71, 906-12. PMID: 26144237

Nota

For research use only.

Isotype Control

Rat IgG1, kappa Recombinant Isotype Control Antibody (RTK2071) (RV080407)

Imágenes