Anti-NTRK1 Polyclonal Antibody (HY107014)

Name: Anti-NTRK1 Polyclonal Antibody
Brand: abinScience
SKU: HY107014
Price: 168 USD
Availability: InStock

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50ug
100ug

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Vista general

Número de catálogo

HY107014

Descripción

Anti-NTRK1 Polyclonal Antibody (HY107014) is a rabbit polyclonal antibody detecting NTRK1 in ELISA, IHC, WB. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

Reactividad de especies

Human

Aplicaciones

ELISA, IHC, WB

Especie huésped

Rabbit

Clonalidad

Polyclonal

Isotipo

IgG

Inmunógeno

E. coli - derived recombinant human NTRK1 (Asp38-Phe378).

Objetivo

High affinity nerve growth factor receptor, EC:2.7.10.1, Neurotrophic tyrosine kinase receptor type 1, TRK1-transforming tyrosine kinase protein, Tropomyosin-related kinase A, Tyrosine kinase receptor, Tyrosine kinase receptor A, Trk-A, gp140trk, p140-TrkA, NTRK1, MTC, TRK, TRKA

Nivel de endotoxinas

Please contact with the lab for this information.

Purificación

Purified by antigen affinity column.

Número de acceso

P04629

Forma

Liquid

Buffer de almacenamiento

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.

Información de uso del producto

Aplicación	Dilución
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Estabilidad y almacenamiento

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Fondo

High affinity nerve growth factor receptor (NTRK1) is a ~87 kDa protein. Receptor tyrosine kinase involved in the development and the maturation of the central and peripheral nervous systems through regulation of proliferation, differentiation and survival of sympathetic and nervous neurons. High affinity receptor for NGF which is its primary ligand. Can also bind and be activated by NTF3/neurotrophin-3. However, NTF3 only supports axonal extension through NTRK1 but has no effect on neuron survival. Upon dimeric NGF ligand-binding, undergoes homodimerization, autophosphorylation and activation.

1. Jing, S. et al. (1992) Neuron 9, 1067-79. PMID: 1281417

2. Tacconelli, A. et al. (2004) Cancer cell 6, 347-60. PMID: 15488758

3. Wehrman, T. et al. (2007) Neuron 53, 25-38. PMID: 17196528

4. Klein, R. et al. (1991) Cell 65, 189-97. PMID: 1849459

5. Hempstead, BL. et al. (1991) Nature 350, 678-83. PMID: 1850821

6. Tong, Q. et al. (2012) FASEB journal : official publication of the Federation of American Societies for Experimental Biology 26, 3811-21. PMID: 22649032

7. Anta, B. et al. (2016) The Journal of biological chemistry 291, 19132-45. PMID: 27445338

8. Barker, PA. et al. (1993) The Journal of biological chemistry 268, 15150-7. PMID: 8325889

Nota

For research use only

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Referencias

Datasheet