Anti-Human ADCYAP1/PACAP Recombinant Antibody (Lilly patent anti-PACAP) (HB716013)

Name: Anti-Human ADCYAP1/PACAP Recombinant Antibody (Lilly patent anti-PACAP)
Brand: abinScience
SKU: HB716013
Price: 191 USD
Availability: InStock

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Spécification :

50ug
100ug
1mg

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SDS

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Numéro de catalogue

HB716013

Description

Anti-Human ADCYAP1/PACAP Recombinant Antibody (Lilly patent anti-PACAP) (HB716013) is a human monoclonal antibody detecting ADCYAP1/PACAP in ELISA, FCM, Functional assay. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

Reactivité des espèces

Human

Applications

ELISA, FCM, Functional assay

Espèce hôte

Human

Clonalité

Monoclonal

Isotype

IgG4, kappa

ID de clone

Lilly patent anti-PACAP

Cible

Pituitary adenylate cyclase-activating polypeptide, PACAP, PACAP-related peptide, PRP-48, Pituitary adenylate cyclase-activating polypeptide 27, PACAP-27, PACAP27, Pituitary adenylate cyclase-activating polypeptide 38, PACAP-38, PACAP38, ADCYAP1

Niveau d'endotoxines

< 10 EU/mg as determined by LAL method.

Pureté

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Numéro d'accès

P18509

Forme

Liquid

Tampon de stockage

0.01M PBS pH 7.4.

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.

Informations d'utilisation du produit

Application	Dilution
ELISA	1:2000-1:20000

Stabilité et stockage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Contexte

Pituitary adenylate cyclase-activating polypeptide (PACAP38) is a ~18 kDa protein. PACAP is a neuropeptide involved in diverse array of physiological processes through activating the PACAP subfamily of class B1 G protein-coupled receptors: VIP receptor 1 (VIPR1), VIP receptor 2 (VIPR2), and PACAP type I receptor (ADCYAP1R1). Exerts neuroprotective and general cytoprotective effects due to anti-apoptotic, anti-inflammatory, and antioxidant actions. Promotes neuron projection development through the RAPGEF2/Rap1/B-Raf/ERK pathway. In chromaffin cells, induces long-lasting increase of intracellular calcium concentrations and neuroendocrine secretion. Involved in the control of glucose homeostasis, induces insulin secretion by pancreatic beta cells.

1. Inooka, H. et al. (2001) Nature structural biology 8, 161-5. PMID: 11175907

2. Emery, AC. et al. (2013) Science signaling 6, ra51. PMID: 23800469

3. Wang, J. et al. (2020) Cell research 30, 436-445. PMID: 32047270

4. Piper, SJ. et al. (2022) Nature communications 13, 7013. PMID: 36385145

Note

For research use only.

Isotype Control

Human IgG4 (S228P) Recombinant Isotype Control Antibody (13R4) (HP298207)

Images

SDS-PAGE

SDS-PAGE for Anti-PACAP38 Antibody (Lilly patent anti-PACAP)

Reférences

Fiche technique

Anti-Human ADCYAP1/PACAP Recombinant Antibody (Lilly patent anti-PACAP).pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Protéines Recombinantes

Anticorps

Kits d'Essai

Anti-Human ADCYAP1/PACAP Recombinant Antibody (Lilly patent anti-PACAP) (HB716013)

Aperçu

Images

Reférences

Fiche technique

SDS