Anti-ADCYAP1 Polyclonal Antibody (HB716014)

Name: Anti-ADCYAP1 Polyclonal Antibody
Brand: abinScience
SKU: HB716014
Price: 168 USD
Availability: InStock

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Overview
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References
Datasheet
SDS

Overview

Catalog No.

HB716014

Species reactivity

Human

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human ADCYAP1 (Ile17-Leu176).

Target

Pituitary adenylate cyclase-activating polypeptide, ADCYAP1, PACAP, PACAP-38, PACAP38, PACAP-27, PACAP27, PRP-48

Purification

Purified by antigen affinity column.

Accession

P18509

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Pituitary adenylate cyclase-activating polypeptide (ADCYAP1/PACAP) is a ~18 kDa protein. PACAP is a neuropeptide involved in diverse array of physiological processes through activating the PACAP subfamily of class B1 G protein-coupled receptors: VIP receptor 1 (VIPR1), VIP receptor 2 (VIPR2), and PACAP type I receptor (ADCYAP1R1). Exerts neuroprotective and general cytoprotective effects due to anti-apoptotic, anti-inflammatory, and antioxidant actions. Promotes neuron projection development through the RAPGEF2/Rap1/B-Raf/ERK pathway. In chromaffin cells, induces long-lasting increase of intracellular calcium concentrations and neuroendocrine secretion. Involved in the control of glucose homeostasis, induces insulin secretion by pancreatic beta cells.

1. Inooka, H. et al. (2001) Nature structural biology 8, 161-5. PMID: 11175907

2. Emery, AC. et al. (2013) Science signaling 6, ra51. PMID: 23800469

3. Wang, J. et al. (2020) Cell research 30, 436-445. PMID: 32047270

4. Piper, SJ. et al. (2022) Nature communications 13, 7013. PMID: 36385145

Note

For research use only.

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References

Datasheet