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| カタログ番号 | HB952043 | ||||
|---|---|---|---|---|---|
| 種反応性 | Human | ||||
| アプリケーション | IF, IHC, IP, WB | ||||
| 宿主種 | Mouse | ||||
| クローン性 | Monoclonal | ||||
| アイソタイプ | IgG2a, kappa | ||||
| クローンID | G2 | ||||
| ターゲット | H2a/x, Histone H2A.X, H2AFX, Histone H2AX, H2AX, gamma H2A.X (phospho S139) | ||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||
| 純度 | >95% as determined by SDS-PAGE. | ||||
| 精製 | Protein A/G purified from cell culture supernatant. | ||||
| アクセッション番号 | P16104 | ||||
| RRID | Anti-Phospho-γ-H2AX (pS139) Antibody (G2) (abinScience Cat# HB952043, RRID:AB_3725745) |
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| 形態 | Liquid | ||||
| 保存バッファー | 0.01M PBS pH 7.4 データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term. | ||||
| 背景 | Histone H2AX (p-γ-H2AX) is a ~15 kDa protein. Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low doses of ionizing radiation and for efficient repair of DNA double strand breaks (DSBs) specifically when modified by C-terminal phosphorylation. | ||||
| 注意事項 | For research use only. |
SDS-PAGE for Anti-Phospho-γ-H2AX (pS139) Antibody (G2).
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