Anti-Phospho-γ-H2AX (pS139) Recombinant Antibody (A9) (HB952023)

Name: Anti-Phospho-γ-H2AX (pS139) Recombinant Antibody (A9)
Brand: abinScience
SKU: HB952023
Price: 191 USD
Availability: InStock

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50ug
100ug
1mg

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Overview
Images
References
Datasheet
SDS

Overview

Catalog No.

HB952023

Species reactivity

Human

Applications

IHC, IP, WB

Host species

Mouse

Isotype

VHH-mFc (IgG2a)

Clone ID

Clonality

Monoclonal

Target

H2a/x, Histone H2A.X, H2AFX, Histone H2AX, H2AX, gamma H2A.X (phospho S139)

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

P16104

RRID

Anti-Phospho-γ-H2AX (pS139) Antibody (A9) (abinScience Cat# HB952023, RRID:AB_3725743)

Form

Liquid

Storage buffer

0.01M PBS pH 7.4

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Background

Histone H2AX (p-γ-H2AX) is a ~15 kDa protein. Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low doses of ionizing radiation and for efficient repair of DNA double strand breaks (DSBs) specifically when modified by C-terminal phosphorylation.

Note

For research use only.

Images

References

Datasheet