Anti-Human LIV-1/Zip6 Polyclonal Antibody (HC424014)

Name: Anti-Human LIV-1/Zip6 Polyclonal Antibody
Brand: abinScience
SKU: HC424014
Price: 168 USD
Availability: InStock

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Spécification :

50ug
100ug

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Reférences
Fiche technique
SDS

Aperçu

Numéro de catalogue

HC424014

Description

Anti-SLC39A6 Polyclonal Antibody (HC424014) is a rabbit polyclonal antibody detecting SLC39A6 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat, and Pongo abelii.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

Reactivité des espèces

Human, Mouse, Rat

Applications

ELISA, IHC, WB

Espèce hôte

Rabbit

Clonalité

Polyclonal

Isotype

IgG

Immunogène

E. coli - derived recombinant Human SLC39A6 (Lys445-Gln656).

Cible

SLC39A6, LIV1, Zrt- and Irt-like protein 6, Zinc transporter ZIP6, ZIP-6, Estrogen-regulated protein LIV-1, Solute carrier family 39 member 6, ZIP6

Niveau d'endotoxines

Please contact with the lab for this information.

Pureté

>95% as determined by SDS-PAGE.

Purification

Purified by antigen affinity column.

Numéro d'accès

Q13433

Forme

Liquid

Tampon de stockage

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.

Informations d'utilisation du produit

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stabilité et stockage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Contexte

Zinc transporter ZIP6 (SLC39A6/LIV-1) is a ~85 kDa protein. Zinc-influx transporter which plays a role in zinc homeostasis and in the induction of epithelial-to-mesenchymal transition (EMT). When associated with SLC39A10, the heterodimer formed by SLC39A10 and SLC39A6 mediates cellular zinc uptake to trigger cells to undergo epithelial- to-mesenchymal transition (EMT). The SLC39A10-SLC39A6 heterodimer also controls NCAM1 phosphorylation and its integration into focal adhesion complexes during EMT. Zinc influx inactivates GSK3B, enabling unphosphorylated SNAI1 in the nucleus to down-regulate adherence genes such as CDH1, causing loss of cell adherence. In addition, the SLC39A10-SLC39A6 heterodimer plays an essentiel role in initiating mitosis by importing zinc into cells to initiate a pathway resulting in the onset of mitosis.

1. Taylor, KM. et al. (2003) The Biochemical journal 375, 51-9. PMID: 12839489

2. Chowanadisai, W. et al. (2008) Brain research 1199, 10-9. PMID: 18272141

3. Yu, M. et al. (2011) The Journal of experimental medicine 208, 775-85. PMID: 21422171

4. Hogstrand, C. et al. (2013) The Biochemical journal 455, 229-37. PMID: 23919497

5. Taylor, KM. et al. (2016) The Biochemical journal 473, 2531-44. PMID: 27274087

6. Kim, B. et al. (2021) Frontiers in immunology 12, 687367. PMID: 34394081

7. Nimmanon, T. et al. (2021) Cellular and molecular life sciences : CMLS 78, 1781-1798. PMID: 32797246

Note

For research use only.

Images

Reférences

Fiche technique

Anti-Human LIV-1/Zip6 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Protéines Recombinantes

Anticorps

Kits d'Essai

Anti-Human LIV-1/Zip6 Polyclonal Antibody (HC424014)

Aperçu

Images

Reférences

Fiche technique

SDS