Anti-Human LIV-1/Zip6 Reference Antibody (Ladiratuzumab, RUO) (HC424016)

Name: Anti-Human LIV-1/Zip6 Reference Antibody (Ladiratuzumab, RUO)
Brand: abinScience
SKU: HC424016
Price: 176 USD
Availability: InStock

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Overview

Catalog No.	HC424016
Description	Ladiratuzumab (HC424016) is a research-grade recombinant antibody targeting SLC39A6. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
Species reactivity	Human
Applications	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Host species	Human
Isotype	IgG1-kappa
Expression system	Mammalian cells
Clonality	Monoclonal
Target	SLC39A6, LIV1, Zrt- and Irt-like protein 6, Zinc transporter ZIP6, ZIP-6, Estrogen-regulated protein LIV-1, Solute carrier family 39 member 6, ZIP6
Endotoxin level	Please contact the lab for this information.
Purity	>95% purity as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	Q13433
Form	Liquid
Storage buffer	0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	hLIV22, SGN-LIV1A, 1629760-28-6
Background	Zinc transporter ZIP6 (SLC39A6/LIV-1) is a ~85 kDa protein. Zinc-influx transporter which plays a role in zinc homeostasis and in the induction of epithelial-to-mesenchymal transition (EMT). When associated with SLC39A10, the heterodimer formed by SLC39A10 and SLC39A6 mediates cellular zinc uptake to trigger cells to undergo epithelial- to-mesenchymal transition (EMT). The SLC39A10-SLC39A6 heterodimer also controls NCAM1 phosphorylation and its integration into focal adhesion complexes during EMT. Zinc influx inactivates GSK3B, enabling unphosphorylated SNAI1 in the nucleus to down-regulate adherence genes such as CDH1, causing loss of cell adherence. In addition, the SLC39A10-SLC39A6 heterodimer plays an essentiel role in initiating mitosis by importing zinc into cells to initiate a pathway resulting in the onset of mitosis. 1. Taylor, KM. et al. (2003) The Biochemical journal 375, 51-9. PMID: 12839489 2. Chowanadisai, W. et al. (2008) Brain research 1199, 10-9. PMID: 18272141 3. Yu, M. et al. (2011) The Journal of experimental medicine 208, 775-85. PMID: 21422171 4. Hogstrand, C. et al. (2013) The Biochemical journal 455, 229-37. PMID: 23919497 5. Taylor, KM. et al. (2016) The Biochemical journal 473, 2531-44. PMID: 27274087 6. Kim, B. et al. (2021) Frontiers in immunology 12, 687367. PMID: 34394081 7. Nimmanon, T. et al. (2021) Cellular and molecular life sciences : CMLS 78, 1781-1798. PMID: 32797246
Note	For research use only. Not suitable for clinical or therapeutic use.

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Bioactivity

SEC-HPLC detection for Research Grade Ladiratuzumab.
SDS-PAGE

SDS-PAGE for Research Grade Ladiratuzumab

References

Datasheet

Anti-Human LIV-1/Zip6 Reference Antibody (Ladiratuzumab, RUO).pdf

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Anti-Human LIV-1/Zip6 Reference Antibody (Ladiratuzumab, RUO) (HC424016)

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