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Anti-Human SLC39A6 Recombinant Antibody (SAA1475), APC (HC424137)

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Overview

Catalog No.	HC424137
Description	Anti-Human SLC39A6 Antibody (SAA1475), APC [SAA1475] (HC424137) is a human monoclonal antibody detecting SLC39A6 in ELISA, FCM. Suitable for Human. Highlights ●Flow Cytometry — Validated for flow cytometry applications. ●Fluorescent Label — Direct conjugate for streamlined workflows.
Species reactivity	Human
Applications	ELISA, FCM
Host species	Human
Isotype	IgG1, kappa
Clone ID	SAA1475
Conjugation	APC
Clonality	Monoclonal
Target	SLC39A6, LIV1, Zrt- and Irt-like protein 6, Zinc transporter ZIP6, ZIP-6, Estrogen-regulated protein LIV-1, Solute carrier family 39 member 6, ZIP6
Endotoxin level	Please contact with the lab for this information.
Accession	Q13433
Form	Liquid
Storage buffer	0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Store at 4°C for 12 months. Protect from light. Do not freeze.
Background	Zinc transporter ZIP6 (SLC39A6/LIV-1) is a ~85 kDa protein. Zinc-influx transporter which plays a role in zinc homeostasis and in the induction of epithelial-to-mesenchymal transition (EMT). When associated with SLC39A10, the heterodimer formed by SLC39A10 and SLC39A6 mediates cellular zinc uptake to trigger cells to undergo epithelial- to-mesenchymal transition (EMT). The SLC39A10-SLC39A6 heterodimer also controls NCAM1 phosphorylation and its integration into focal adhesion complexes during EMT. Zinc influx inactivates GSK3B, enabling unphosphorylated SNAI1 in the nucleus to down-regulate adherence genes such as CDH1, causing loss of cell adherence. In addition, the SLC39A10-SLC39A6 heterodimer plays an essentiel role in initiating mitosis by importing zinc into cells to initiate a pathway resulting in the onset of mitosis. 1. Taylor, KM. et al. (2003) The Biochemical journal 375, 51-9. PMID: 12839489 2. Chowanadisai, W. et al. (2008) Brain research 1199, 10-9. PMID: 18272141 3. Yu, M. et al. (2011) The Journal of experimental medicine 208, 775-85. PMID: 21422171 4. Hogstrand, C. et al. (2013) The Biochemical journal 455, 229-37. PMID: 23919497 5. Taylor, KM. et al. (2016) The Biochemical journal 473, 2531-44. PMID: 27274087 6. Kim, B. et al. (2021) Frontiers in immunology 12, 687367. PMID: 34394081 7. Nimmanon, T. et al. (2021) Cellular and molecular life sciences : CMLS 78, 1781-1798. PMID: 32797246
Note	For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only.

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Anti-Human SLC39A6 Recombinant Antibody (SAA1475), APC.pdf

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Anti-Human SLC39A6 Recombinant Antibody (SAA1475), APC