Please ensure Javascript is enabled for purposes of website accessibility
お問い合わせ お問い合わせ
JP
ホーム > 製品 > 抗体 > 1次抗体

Anti-Human LIV-1/Zip6 Polyclonal Antibody (HC424014)

データシート 製品共有 情報コピー
価格(USD): --
スペック:
  • 50ug
  • 100ug
数量:
お問い合わせ

  • 概要

  • イメージ

  • 参考文献

  • データシート

  • SDS

概要
カタログ番号HC424014
説明
Anti-SLC39A6 Polyclonal Antibody (HC424014) is a rabbit polyclonal antibody detecting SLC39A6 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat, and Pongo abelii.
Highlights
  • ●Affinity Purified — Minimal background and high purity for reliable results.
  • ●Multi-Application — Validated across multiple applications.
  • ●Multi-Species — Cross-reactive for translational research.
種反応性Human, Mouse, Rat
アプリケーションELISA, IHC, WB
宿主種Rabbit
クローン性Polyclonal
アイソタイプIgG
免疫原 E. coli - derived recombinant Human SLC39A6 (Lys445-Gln656).
ターゲット SLC39A6, LIV1, Zrt- and Irt-like protein 6, Zinc transporter ZIP6, ZIP-6, Estrogen-regulated protein LIV-1, Solute carrier family 39 member 6, ZIP6
エンドトキシンレベル Please contact with the lab for this information.
純度 >95% as determined by SDS-PAGE.
精製 Purified by antigen affinity column.
アクセッション番号 Q13433
形態 Liquid
保存バッファー 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。
製品使用情報
アプリケーション 希釈
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
安定性と保存 Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景

Zinc transporter ZIP6 (SLC39A6/LIV-1) is a ~85 kDa protein. Zinc-influx transporter which plays a role in zinc homeostasis and in the induction of epithelial-to-mesenchymal transition (EMT). When associated with SLC39A10, the heterodimer formed by SLC39A10 and SLC39A6 mediates cellular zinc uptake to trigger cells to undergo epithelial- to-mesenchymal transition (EMT). The SLC39A10-SLC39A6 heterodimer also controls NCAM1 phosphorylation and its integration into focal adhesion complexes during EMT. Zinc influx inactivates GSK3B, enabling unphosphorylated SNAI1 in the nucleus to down-regulate adherence genes such as CDH1, causing loss of cell adherence. In addition, the SLC39A10-SLC39A6 heterodimer plays an essentiel role in initiating mitosis by importing zinc into cells to initiate a pathway resulting in the onset of mitosis.

1. Taylor, KM. et al. (2003) The Biochemical journal 375, 51-9. PMID: 12839489
2. Chowanadisai, W. et al. (2008) Brain research 1199, 10-9. PMID: 18272141
3. Yu, M. et al. (2011) The Journal of experimental medicine 208, 775-85. PMID: 21422171
4. Hogstrand, C. et al. (2013) The Biochemical journal 455, 229-37. PMID: 23919497
5. Taylor, KM. et al. (2016) The Biochemical journal 473, 2531-44. PMID: 27274087
6. Kim, B. et al. (2021) Frontiers in immunology 12, 687367. PMID: 34394081
7. Nimmanon, T. et al. (2021) Cellular and molecular life sciences : CMLS 78, 1781-1798. PMID: 32797246
注意事項 For research use only.
イメージ
参考文献
データシート
Download SDS PDF
Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.
Mass
=
Concentration
×
Volume
Molecular Weight *
g/mol
Formula
C₁ × V₁ = C₂ × V₂
Enter any 3 of the 4 values to solve for the unknown.
Stock Solution
C₁ (Stock Conc.)
×
V₁ (Stock Vol.)
=
Working Solution
C₂ (Working Conc.)
×
V₂ (Working Vol.)
レコメンデーション

お問い合わせ カスタムクォート、大量リクエストおよびその他の問題については

メール: [email protected]

ディストリビューターリスト

無料クォート取得
Anti-Human LIV-1/Zip6 Polyclonal Antibody

クイックアクセス

お問い合わせ

  • +86-027-65523339

  • [email protected]

  • 中国武漢市深敦寺路666号C棟、武漢、430206

  • linkedin
  • Ins
  • youtube
  • youtube
著作権 © 2026 abinScience. 全ての権利を留保します。 すべての製品は研究用途にのみ使用してください