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| カタログ番号 | HC445014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-TDP43 Polyclonal Antibody (HC445014) is a rabbit polyclonal antibody detecting TDP43 in ELISA, IHC, WB. Suitable for Human, Mouse, Chicken, Pongo abelii, and Xenopus tropicalis.
Highlights
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| 種反応性 | Human, Mouse | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human TARDBP (Ser104-Pro262). | ||||||||
| ターゲット | TAR DNA-binding protein 43, TARDBP, TDP-43, TDP43 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q13148 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | TAR DNA-binding protein 43 (TARDBP/TDP43) is a ~44 kDa protein. RNA-binding protein that is involved in various steps of RNA biogenesis and processing. Preferentially binds, via its two RNA recognition motifs RRM1 and RRM2, to GU-repeats on RNA molecules predominantly localized within long introns and in the 3'UTR of mRNAs. In turn, regulates the splicing of many non-coding and protein-coding RNAs including proteins involved in neuronal survival, as well as mRNAs that encode proteins relevant for neurodegenerative diseases. Plays a role in maintaining mitochondrial homeostasis by regulating the processing of mitochondrial transcripts. Also regulates mRNA stability by recruiting CNOT7/CAF1 deadenylase on mRNA 3'UTR leading to poly(A) tail deadenylation and thus shortening. 1. Bhardwaj, A. et al. (2013) Nucleic acids research 41, 5062-74. PMID: 23519609 2. Lukavsky, PJ. et al. (2013) Nature structural & molecular biology 20, 1443-9. PMID: 24240615 3. Kuo, PH. et al. (2014) Nucleic acids research 42, 4712-22. PMID: 24464995 4. Tollervey, JR. et al. (2011) Nature neuroscience 14, 452-8. PMID: 21358640 5. Wang, A. et al. (2018) The EMBO journal 37. PMID: 29438978 6. Izumikawa, K. et al. (2017) Scientific reports 7, 7709. PMID: 28794432 7. Fukushima, M. et al. (2019) FEBS letters 593, 277-287. PMID: 30520513 8. Colombrita, C. et al. (2009) Journal of neurochemistry 111, 1051-61. PMID: 19765185 9. Higashi, S. et al. (2013) Journal of neurochemistry 126, 288-300. PMID: 23398327 | ||||||||
| 注意事項 | For research use only. |
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