Anti-Human pTDP43(Ser403/Ser404) Recombinant Antibody (SAA2033) (HC445053)

Name: Anti-Human pTDP43(Ser403/Ser404) Recombinant Antibody (SAA2033)
Brand: abinScience
SKU: HC445053
Price: 110 USD
Availability: InStock

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Overview
Images
References
Datasheet
SDS

Overview

Catalog No.

HC445053

Species reactivity

Human

Applications

ELISA, WB

Host species

Mouse

Isotype

IgG2a

Clone ID

SAA2033

Clonality

Monoclonal

Target

Phospho-TDP43 (Ser403, Ser404), pTDP43(403/404), phospho TDP-43 (Ser409/Ser410)

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

Q13148

RRID

Anti-Human pTDP43(Ser403/Ser404) Antibody (SAA2033) (abinScience Cat# HC445053, RRID:AB_3728959)
_x005F_x000D_

Form

Liquid

Storage buffer

0.01M PBS pH 7.4

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:2000-1:20000
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Background

TAR DNA-binding protein 43 (pTARDBP/pTDP43) is a ~44 kDa protein. RNA-binding protein that is involved in various steps of RNA biogenesis and processing. Preferentially binds, via its two RNA recognition motifs RRM1 and RRM2, to GU-repeats on RNA molecules predominantly localized within long introns and in the 3'UTR of mRNAs. In turn, regulates the splicing of many non-coding and protein-coding RNAs including proteins involved in neuronal survival, as well as mRNAs that encode proteins relevant for neurodegenerative diseases. Plays a role in maintaining mitochondrial homeostasis by regulating the processing of mitochondrial transcripts. Also regulates mRNA stability by recruiting CNOT7/CAF1 deadenylase on mRNA 3'UTR leading to poly(A) tail deadenylation and thus shortening.

1. Bhardwaj, A. et al. (2013) Nucleic acids research 41, 5062-74. PMID: 23519609

2. Lukavsky, PJ. et al. (2013) Nature structural & molecular biology 20, 1443-9. PMID: 24240615

3. Kuo, PH. et al. (2014) Nucleic acids research 42, 4712-22. PMID: 24464995

4. Tollervey, JR. et al. (2011) Nature neuroscience 14, 452-8. PMID: 21358640

5. Wang, A. et al. (2018) The EMBO journal 37. PMID: 29438978

6. Izumikawa, K. et al. (2017) Scientific reports 7, 7709. PMID: 28794432

7. Fukushima, M. et al. (2019) FEBS letters 593, 277-287. PMID: 30520513

8. Colombrita, C. et al. (2009) Journal of neurochemistry 111, 1051-61. PMID: 19765185

9. Higashi, S. et al. (2013) Journal of neurochemistry 126, 288-300. PMID: 23398327

Note

For research use only.

Images

SDS-PAGE

SDS-PAGE for Anti-Human pTDP43(Ser403/Ser404) Antibody (SAA2033).

References

Datasheet

Anti-Human pTDP43(Ser403/Ser404) Recombinant Antibody (SAA2033).pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

Assay Kits

Anti-Human pTDP43(Ser403/Ser404) Recombinant Antibody (SAA2033) (HC445053)

Overview

Images

References

Datasheet

SDS

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