Human CALCR/Calcitonin receptor/CT-R Recombinant Protein (C-Fc) (HB973011)

Name: Human CALCR/Calcitonin receptor/CT-R Recombinant Protein (C-Fc)
Brand: abinScience
SKU: HB973011
Price: 298 USD
Availability: InStock

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Numéro de catalogue	HB973011
Description	Recombinant Human CALCR/Calcitonin receptor/CT-R Protein, C-Fc (HB973011) expressed in Mammalian Cells, spanning Ala25-Ile153. Purity: >90% by SDS-PAGE. Highlights ●Fc Fusion — Enhanced stability with Protein A/G purification compatibility. ●Mammalian Expression — Proper folding and native glycosylation. ●High Purity — >90% purity verified by SDS-PAGE.
Système d'expression	Mammalian cells
Numéro d'accès	P30988
Longueur de protéine	Ala25-Ile153
Applications	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Espèces	Homo sapiens (Human)
Nature	Recombinant
Niveau d'endotoxines	Please contact with the lab for this information.
Pureté	>90% as determined by SDS-PAGE.
Masse moléculaire prédite	43.68 kDa
Forme	Lyophilized
Tampon de stockage	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Expédition	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stabilité et stockage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Noms alternatifs	CALCR, CT-R, Calcitonin receptor
Contexte	Calcitonin receptor is a ~55 kDa protein. G protein-coupled receptor activated by ligand peptides amylin (IAPP), calcitonin (CT/CALCA) and calcitonin gene-related peptide type 1 (CGRP1/CALCA). CALCR interacts with receptor-activity-modifying proteins RAMP1, 2 and 3 to form receptor complexes AMYR1, 2 and 3, respectively. IAPP, CT and CGRP1 activate CALCR and AMYRs with distinct modes of receptor activation resulting in specific phenotypes. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors. Activates cAMP-dependent pathway. 1. Cao, J. et al. (2022) Science (New York, N.Y.) 375, eabm9609. PMID: 35324283 2. Cao, J. et al. (2024) Biochemistry 63, 1089-1096. PMID: 38603770 3. Moore, EE. et al. (1995) Molecular endocrinology (Baltimore, Md.) 9, 959-68. PMID: 7476993
Note	For research use only

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Human CALCR/Calcitonin receptor/CT-R Recombinant Protein (C-Fc).pdf

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