Human CALCR/Calcitonin receptor/CT-R Recombinant Protein (N-His) (HB973012)

Name: Human CALCR/Calcitonin receptor/CT-R Recombinant Protein (N-His)
Brand: abinScience
SKU: HB973012
Price: 211 USD
Availability: InStock

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Overview

Catalog No.	HB973012
Description	Recombinant Human CALCR/Calcitonin receptor/CT-R Protein, N-His (HB973012) expressed in E. coli, spanning Lys37-Ala152. Purity: >90% by SDS-PAGE. Highlights ●His-Tagged — N-terminal 6×His tag for IMAC purification. ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% purity verified by SDS-PAGE.
Expression system	E. coli
Accession	P30988
Protein length	Lys37-Ala152
Applications	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Species	Homo sapiens (Human)
Nature	Recombinant
Endotoxin level	Please contact with the lab for this information.
Purity	>90% as determined by SDS-PAGE.
Predicted molecular weight	16.18 kDa
Form	Lyophilized
Storage buffer	Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Reconstitution	Reconstitute in sterile water for a stock solution. Adjust the volume of sterile water so that, after reconstitution, the final stock concentration matches the value indicated on the product label or datasheet. RECONSTITUTION PROTOCOL 1. Allow the product to be reconstituted and the reconstitution diluent to reach room temperature. 2. Tap or briefly centrifuge the product vial before opening to dislodge any lyophilized material that may be dispersed on the wall or cap of the vial. 3. Use the diluent and stock concentration recommended in the product datasheet. If preparing a stock concentration higher than recommended, contact Technical Service. 4. After adding the diluent, re-cap the vial and invert gently by hand or place on a slow rocking platform to allow the reconstitution diluent to coat all the surfaces inside the vial. Note: Do not mix by vortexing or by pipetting the material up and down. 5. Allow the vial to sit at room temperature with gentle agitation for at least 15 minutes before aliquotting or using. 6. Store the reconstituted material in single use aliquots in polypropylene or siliconized tubes. Aliquots of 10 μL or larger are recommended.
Shipping	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	CT-R, CALCR, Calcitonin receptor
Background	Calcitonin receptor (CALCR/CT-R) is a ~55 kDa protein. G protein-coupled receptor activated by ligand peptides amylin (IAPP), calcitonin (CT/CALCA) and calcitonin gene-related peptide type 1 (CGRP1/CALCA). CALCR interacts with receptor-activity-modifying proteins RAMP1, 2 and 3 to form receptor complexes AMYR1, 2 and 3, respectively. IAPP, CT and CGRP1 activate CALCR and AMYRs with distinct modes of receptor activation resulting in specific phenotypes. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors. Activates cAMP-dependent pathway. 1. Cao, J. et al. (2022) Science (New York, N.Y.) 375, eabm9609. PMID: 35324283 2. Cao, J. et al. (2024) Biochemistry 63, 1089-1096. PMID: 38603770 3. Moore, EE. et al. (1995) Molecular endocrinology (Baltimore, Md.) 9, 959-68. PMID: 7476993
Note	For research use only.

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SDS-PAGE for Recombinant Human CALCR/Calcitonin receptor/CT-R Protein, N-His

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HB973012-SDS-PAGE-1.jpg

Datasheet

Human CALCR/Calcitonin receptor/CT-R Recombinant Protein (N-His).pdf

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Human CALCR/Calcitonin receptor/CT-R Recombinant Protein (N-His) (HB973012)

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