Anti-Human CALCR/Calcitonin receptor/CT-R Recombinant Antibody (SAA1757) (HB973013)

Name: Anti-Human CALCR/Calcitonin receptor/CT-R Recombinant Antibody (SAA1757)
Brand: abinScience
SKU: HB973013
Price: 196 USD
Availability: InStock

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References
Datasheet
SDS

Overview

Catalog No.

HB973013

Species reactivity

Human

Applications

ELISA

Host species

Mouse

Isotype

IgG2a, kappa

Clone ID

SAA1757

Clonality

Monoclonal

Target

CT-R, CALCR, Calcitonin receptor

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

P30988

RRID

Anti-Human CALCR/Calcitonin receptor/CT-R Antibody (SAA1757) (abinScience Cat# HB973013, RRID:AB_3727518)

Form

Liquid

Storage buffer

0.01M PBS pH 7.4

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:2000-1:20000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Background

Calcitonin receptor (CALCR/CT-R) is a ~55 kDa protein. G protein-coupled receptor activated by ligand peptides amylin (IAPP), calcitonin (CT/CALCA) and calcitonin gene-related peptide type 1 (CGRP1/CALCA). CALCR interacts with receptor-activity-modifying proteins RAMP1, 2 and 3 to form receptor complexes AMYR1, 2 and 3, respectively. IAPP, CT and CGRP1 activate CALCR and AMYRs with distinct modes of receptor activation resulting in specific phenotypes. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors. Activates cAMP-dependent pathway.

1. Cao, J. et al. (2022) Science (New York, N.Y.) 375, eabm9609. PMID: 35324283

2. Cao, J. et al. (2024) Biochemistry 63, 1089-1096. PMID: 38603770

3. Moore, EE. et al. (1995) Molecular endocrinology (Baltimore, Md.) 9, 959-68. PMID: 7476993

Note

For research use only.

Images

SDS-PAGE

SDS-PAGE for Anti-Human CALCR/Calcitonin receptor/CT-R Antibody (SAA1757)

References

Datasheet

Anti-Human CALCR/Calcitonin receptor/CT-R Recombinant Antibody (SAA1757).pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

Assay Kits

Anti-Human CALCR/Calcitonin receptor/CT-R Recombinant Antibody (SAA1757) (HB973013)

Overview

Images

References

Datasheet

SDS

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