Human NKG2A/CD159a Recombinant Protein (N-Fc) (HB188011)

Name: Human NKG2A/CD159a Recombinant Protein (N-Fc)
Brand: abinScience
SKU: HB188011
Price: 298 USD
Availability: InStock

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1mg

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概要
イメージ
参考文献
データシート
SDS

概要

カタログ番号	HB188011
説明	Recombinant Human CD159a/KLRC1 Protein, N-Fc (HB188011) expressed in Mammalian Cells, spanning Pro94-Leu233. Purity: >90% by SDS-PAGE. Highlights ●Fc Fusion — Enhanced stability with Protein A/G purification compatibility. ●Mammalian Expression — Proper folding and native glycosylation. ●High Purity — >90% purity verified by SDS-PAGE.
発現システム	Mammalian cells
アクセッション番号	P26715
タンパク質長	Pro94-Leu233
アプリケーション	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
種	Homo sapiens (Human)
性質	Recombinant
エンドトキシンレベル	Please contact with the lab for this information.
純度	>90% as determined by SDS-PAGE.
予測分子量	43.85 kDa
形態	Lyophilized
保存バッファー	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。
再構成	Reconstitute in sterile water for a stock solution. Adjust the volume of sterile water so that, after reconstitution, the final stock concentration matches the value indicated on the product label or datasheet. RECONSTITUTION PROTOCOL 1. Allow the product to be reconstituted and the reconstitution diluent to reach room temperature. 2. Tap or briefly centrifuge the product vial before opening to dislodge any lyophilized material that may be dispersed on the wall or cap of the vial. 3. Use the diluent and stock concentration recommended in the product datasheet. If preparing a stock concentration higher than recommended, contact Technical Service. 4. After adding the diluent, re-cap the vial and invert gently by hand or place on a slow rocking platform to allow the reconstitution diluent to coat all the surfaces inside the vial. Note: Do not mix by vortexing or by pipetting the material up and down. 5. Allow the vial to sit at room temperature with gentle agitation for at least 15 minutes before aliquotting or using. 6. Store the reconstituted material in single use aliquots in polypropylene or siliconized tubes. Aliquots of 10 μL or larger are recommended.
発送	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
安定性と保存	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
別名	KLRC1, NKG2-A/NKG2-B type II integral membrane protein, NKG2-A/B-activating NK receptor, CD159 antigen-like family member A, CD159a, NK cell receptor A, NKG2A
背景	NKG2-A/NKG2-B type II integral membrane protein (CD159a/KLRC1) is a ~26 kDa protein. Immune inhibitory receptor involved in self-nonself discrimination. In complex with KLRD1 on cytotoxic and regulatory lymphocyte subsets, recognizes non-classical major histocompatibility (MHC) class Ib molecule HLA-E loaded with self-peptides derived from the signal sequence of classical MHC class Ia molecules. Enables cytotoxic cells to monitor the expression of MHC class I molecules in healthy cells and to tolerate self. Upon HLA-E-peptide binding, transmits intracellular signals through two immunoreceptor tyrosine-based inhibition motifs (ITIMs) by recruiting INPP5D/SHP-1 and INPPL1/SHP-2 tyrosine phosphatases to ITIMs, and ultimately opposing signals transmitted by activating receptors through dephosphorylation of proximal signaling molecules. Key inhibitory receptor on natural killer (NK) cells that regulates their activation and effector functions. 1. Sullivan, LC. et al. (2007) Immunity 27, 900-11. PMID: 18083576 2. Lin, Z. et al. (2023) Nature immunology 24, 1087-1097. PMID: 37264229 3. Valiante, NM. et al. (1997) Immunity 7, 739-51. PMID: 9430220 4. Braud, VM. et al. (1998) Nature 391, 795-9. PMID: 9486650 5. Kabat, J. et al. (2002) Journal of immunology (Baltimore, Md. : 1950) 169, 1948-58. PMID: 12165520 6. Le Dréan, E. et al. (1998) European journal of immunology 28, 264-76. PMID: 9485206 7. Kamiya, T. et al. (2019) The Journal of clinical investigation 129, 2094-2106. PMID: 30860984 8. Jabri, B. et al. (2002) Immunity 17, 487-99. PMID: 12387742 9. Bhagat, G. et al. (2008) The Journal of clinical investigation 118, 281-93. PMID: 18064301
注意事項	For research use only.