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Human PD-1 Recombinant Protein (C-His) (HS870021)

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Human PD-1 Recombinant Protein (C-His)
Human PD-1 Recombinant Protein (C-His)
Human PD-1 Recombinant Protein (C-His)
Human PD-1 Recombinant Protein (C-His)
Human PD-1 Recombinant Protein (C-His)
Human PD-1 Recombinant Protein (C-His)
Human PD-1 Recombinant Protein (C-His)
Human PD-1 Recombinant Protein (C-His)
Human PD-1 Recombinant Protein (C-His)
Human PD-1 Recombinant Protein (C-His)
Human PD-1 Recombinant Protein (C-His)
Human PD-1 Recombinant Protein (C-His)
Human PD-1 Recombinant Protein (C-His)
Human PD-1 Recombinant Protein (C-His)
Human PD-1 Recombinant Protein (C-His)
Human PD-1 Recombinant Protein (C-His)
Human PD-1 Recombinant Protein (C-His)
Human PD-1 Recombinant Protein (C-His)
Human PD-1 Recombinant Protein (C-His)
Human PD-1 Recombinant Protein (C-His)
Human PD-1 Recombinant Protein (C-His)
Human PD-1 Recombinant Protein (C-His)
Human PD-1 Recombinant Protein (C-His)
Human PD-1 Recombinant Protein (C-His)
Human PD-1 Recombinant Protein (C-His)
Human PD-1 Recombinant Protein (C-His)
Human PD-1 Recombinant Protein (C-His)
Human PD-1 Recombinant Protein (C-His)
Human PD-1 Recombinant Protein (C-His)
Human PD-1 Recombinant Protein (C-His)
Human PD-1 Recombinant Protein (C-His)
Human PD-1 Recombinant Protein (C-His)
Human PD-1 Recombinant Protein (C-His)
Human PD-1 Recombinant Protein (C-His)
Human PD-1 Recombinant Protein (C-His)
Human PD-1 Recombinant Protein (C-His)
Human PD-1 Recombinant Protein (C-His)
Human PD-1 Recombinant Protein (C-His)
Human PD-1 Recombinant Protein (C-His)
Human PD-1 Recombinant Protein (C-His)
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概要
カタログ番号HS870021
説明
Recombinant Human CD279/PDCD1/PD1 Protein, C-His (HS870021) expressed in Mammalian Cells, spanning Pro21-Gln167. Purity: >90% by SDS-PAGE.
Highlights
  • ●His-Tagged — N-terminal 6×His tag for IMAC purification.
  • ●Mammalian Expression — Proper folding and native glycosylation.
  • ●High Purity — >90% purity verified by SDS-PAGE.
発現システムMammalian cells
アクセッション番号Q15116
タンパク質長Pro21-Gln167
アプリケーションELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
種Homo sapiens (Human)
性質 Recombinant
ターゲット CD279, PD1, PDCD1, Programmed cell death protein 1, Protein PD-1, PD-1
エンドトキシンレベル Please contact with the lab for this information.
純度 >90% as determined by SDS-PAGE.
予測分子量 19.73 kDa
形態 Lyophilized
保存バッファー Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol.

データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。
再構成 Reconstitute in sterile water for a stock solution. Adjust the volume of sterile water so that, after reconstitution, the final stock concentration matches the value indicated on the product label or datasheet.

RECONSTITUTION PROTOCOL
1. Allow the product to be reconstituted and the reconstitution diluent to reach room temperature.
2. Tap or briefly centrifuge the product vial before opening to dislodge any lyophilized material that may be dispersed on the wall or cap of the vial.
3. Use the diluent and stock concentration recommended in the product datasheet. If preparing a stock concentration higher than recommended, contact Technical Service.
4. After adding the diluent, re-cap the vial and invert gently by hand or place on a slow rocking platform to allow the reconstitution diluent to coat all the surfaces inside the vial. Note: Do not mix by vortexing or by pipetting the material up and down.
5. Allow the vial to sit at room temperature with gentle agitation for at least 15 minutes before aliquotting or using.
6. Store the reconstituted material in single use aliquots in polypropylene or siliconized tubes. Aliquots of 10 μL or larger are recommended.
発送 In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
安定性と保存 Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
別名CD279, PD1, PDCD1, Programmed cell death protein 1, Protein PD-1, PD-1
背景

Programmed cell death protein 1 (CD279/PD-1) is a ~31 kDa protein. Inhibitory receptor on antigen activated T-cells that plays a critical role in induction and maintenance of immune tolerance to self. Delivers inhibitory signals upon binding to ligands CD274/PDCD1L1 and CD273/PDCD1LG2. Following T-cell receptor (TCR) engagement, PDCD1 associates with TCR-CD3 in the immunological synapse and directly inhibits T-cell activation. Suppresses T-cell activation through the recruitment of PTPN11/SHP-2: following ligand-binding, PDCD1 is phosphorylated within the ITSM motif, leading to the recruitment of the protein tyrosine phosphatase PTPN11/SHP-2 that mediates dephosphorylation of key TCR proximal signaling molecules, such as ZAP70, PRKCQ/PKCtheta and CD247/CD3zeta. CD279 is the therapeutic target of pembrolizumab (Keytruda) and nivolumab (Opdivo).

1. Fife, BT. et al. (2011) Annals of the New York Academy of Sciences 1217, 45-59. PMID: 21276005
2. Bardhan, K. et al. (2019) Scientific reports 9, 17252. PMID: 31754127
3. Patsoukis, N. et al. (2020) Communications biology 3, 128. PMID: 32184441
4. Xiao, X. et al. (2023) Nature communications 14, 2859. PMID: 37208329
5. Zak, KM. et al. (2015) Structure (London, England : 1993) 23, 2341-2348. PMID: 26602187
注意事項 For research use only.
イメージ
  • Human PD-1 Recombinant Protein (C-His)

    SDS-PAGE

    SDS-PAGE for Human PD-1 Recombinant Protein (C-His)

  • Human PD-1 Recombinant Protein (C-His)

    Bioactivity

    Detects Penpulimab in indirect ELISAs.

  • Human PD-1 Recombinant Protein (C-His)

    Bioactivity

    Detects Vudalimab in indirect ELISAs.

  • Human PD-1 Recombinant Protein (C-His)

    Bioactivity

    Detects Rosnilimab in indirect ELISAs.

  • Human PD-1 Recombinant Protein (C-His)

    Bioactivity

    Detects Nofazinlimab in indirect ELISAs.

  • Human PD-1 Recombinant Protein (C-His)

    Bioactivity

    Detects Camrelizumab in indirect ELISAs.

  • Human PD-1 Recombinant Protein (C-His)

    Bioactivity

    Detected by Research Grade Reozalimab in indirect ELISA.

  • Human PD-1 Recombinant Protein (C-His)

    Bioactivity

    Detected by Research Grade Volrustomig (Cat No.: HS870396) inindirectELISA.

  • Human PD-1 Recombinant Protein (C-His)

    Bioactivity

    Detected by Research Grade Reozalimab (Cat No.: HV974216) inindirectELISA.

  • Human PD-1 Recombinant Protein (C-His)

    Bioactivity

    Detected by Research Grade Ivonescimab (Cat No.: HB941056) inindirectELISA.

  • Human PD-1 Recombinant Protein (C-His)

    Bioactivity

    Detected by Research Grade Geptanolimab (Cat No.: HS870246) in indirect ELISA.

  • Human PD-1 Recombinant Protein (C-His)

    Bioactivity

    Detected by Fanastomig (Catalog No: HB613246) in indirect ELISA.

  • Human PD-1 Recombinant Protein (C-His)

    Bioactivity

    Detected by Cugrastomig (Catalog No: HB613276) in indirect ELISA.

  • Human PD-1 Recombinant Protein (C-His)

    Bioactivity

    Detected by Lorigerlimab (Catalog No: HB651086) in indirect ELISA.

  • Human PD-1 Recombinant Protein (C-His)

    Bioactivity

    Detected by Acrixolimab (Catalog No: HS870156) in indirect ELISA.

  • Human PD-1 Recombinant Protein (C-His)

    Bioactivity

    Detected by Zeluvalimab (Catalog No: HS870276) in indirect ELISA.

  • Human PD-1 Recombinant Protein (C-His)

    Bioactivity

    Detected by Zimbirelimab (Catalog No: HS870296) in indirect ELISA.

  • Human PD-1 Recombinant Protein (C-His)

    Bioactivity

    Detected by Pradusinstobart (Catalog No: HS870376) in indirect ELISA.

  • Human PD-1 Recombinant Protein (C-His)

    Bioactivity

    Detected by Danvilostomig (Catalog No: HS870386) in indirect ELISA.

  • Human PD-1 Recombinant Protein (C-His)

    Bioactivity

    Detected by Lomvastomig (Catalog No: HV029046) in indirect ELISA.

参考文献
データシート
Download SDS PDF
Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.
Mass
=
Concentration
×
Volume
Molecular Weight *
g/mol
Formula
C₁ × V₁ = C₂ × V₂
Enter any 3 of the 4 values to solve for the unknown.
Stock Solution
C₁ (Stock Conc.)
×
V₁ (Stock Vol.)
=
Working Solution
C₂ (Working Conc.)
×
V₂ (Working Vol.)
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Human PD-1 Recombinant Protein (C-His)

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