Human Leptin R Recombinant Protein (C-Fc) (HW637021)

Name: Human Leptin R Recombinant Protein (C-Fc)
Brand: abinScience
SKU: HW637021
Price: 298 USD
Availability: InStock

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1mg

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Número de catálogo	HW637021
Descripción	Recombinant Human CD295/LEPR Protein, C-Fc (HW637021) expressed in Mammalian Cells, spanning Met1-Asp839. Purity: >90% by SDS-PAGE. Highlights ●Fc Fusion — Enhanced stability with Protein A/G purification compatibility. ●Mammalian Expression — Proper folding and native glycosylation. ●High Purity — >90% purity verified by SDS-PAGE.
Sistema de expresión	Mammalian cells
Número de acceso	P48357
Longitud de proteína	Met1-Asp839
Aplicaciones	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Especies	Homo sapiens (Human)
Naturaleza	Recombinant
Nivel de endotoxinas	Please contact with the lab for this information.
Pureza	>90% as determined by SDS-PAGE.
Peso molecular predicho	122.44 kDa
Forma	Lyophilized
Buffer de almacenamiento	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Reconstitución	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Envío	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Estabilidad y almacenamiento	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Nombres alternativos	CD295, DB, HuB219, LEP-R, LEPR, Leptin receptor, OB receptor, OB-R, OBR
Fondo	Leptin receptor is a ~132 kDa protein. Receptor for hormone LEP/leptin (Probable). On ligand binding, mediates LEP central and peripheral effects through the activation of different signaling pathways such as JAK2/STAT3 and MAPK cascade/FOS. In the hypothalamus, LEP acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, increases basal metabolism, influences reproductive function, regulates pancreatic beta-cell function and insulin secretion, is pro-angiogenic and affects innate and adaptive immunity. Control of energy homeostasis and melanocortin production (stimulation of POMC and full repression of AgRP transcription) is mediated by STAT3 signaling, whereas distinct signals regulate NPY and the control of fertility, growth and glucose homeostasis. 1. Carpenter, B. et al. (2012) Structure (London, England : 1993) 20, 487-97. PMID: 22405007 2. Clément, K. et al. (1998) Nature 392, 398-401. PMID: 9537324 3. Zhao, Y. et al. (2003) Biochemical and biophysical research communications 300, 247-52. PMID: 12504075 4. Cassano, S. et al. (2014) Metabolism: clinical and experimental 63, 1272-9. PMID: 25060689 5. Bennett, BD. et al. (1996) Current biology : CB 6, 1170-80. PMID: 8805376
Nota	For research use only

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Datasheet

Human Leptin R Recombinant Protein (C-Fc).pdf

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Formula

C₁ × V₁ = C₂ × V₂

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Working Solution

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