Human ROR1 Recombinant Protein (C-His) (HX065011)

Name: Human ROR1 Recombinant Protein (C-His)
Brand: abinScience
SKU: HX065011
Price: 298 USD
Availability: InStock

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Aperçu

Numéro de catalogue	HX065011
Description	Recombinant Human ROR1 Protein, C-His (HX065011) expressed in Mammalian Cells, spanning Gln30-Tyr406. Purity: >90% by SDS-PAGE. Highlights ●His-Tagged — N-terminal 6×His tag for IMAC purification. ●Mammalian Expression — Proper folding and native glycosylation. ●High Purity — >90% purity verified by SDS-PAGE.
Système d'expression	Mammalian cells
Numéro d'accès	Q01973
Longueur de protéine	Gln30-Tyr406
Applications	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Espèces	Homo sapiens (Human)
Nature	Recombinant
Applications testées	WB
Niveau d'endotoxines	Please contact with the lab for this information.
Pureté	>90% as determined by SDS-PAGE.
Masse moléculaire prédite	45.67 kDa
Forme	Lyophilized
Tampon de stockage	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.
Reconstitution	Reconstitute in sterile water for a stock solution. Adjust the volume of sterile water so that, after reconstitution, the final stock concentration matches the value indicated on the product label or datasheet. RECONSTITUTION PROTOCOL 1. Allow the product to be reconstituted and the reconstitution diluent to reach room temperature. 2. Tap or briefly centrifuge the product vial before opening to dislodge any lyophilized material that may be dispersed on the wall or cap of the vial. 3. Use the diluent and stock concentration recommended in the product datasheet. If preparing a stock concentration higher than recommended, contact Technical Service. 4. After adding the diluent, re-cap the vial and invert gently by hand or place on a slow rocking platform to allow the reconstitution diluent to coat all the surfaces inside the vial. Note: Do not mix by vortexing or by pipetting the material up and down. 5. Allow the vial to sit at room temperature with gentle agitation for at least 15 minutes before aliquotting or using. 6. Store the reconstituted material in single use aliquots in polypropylene or siliconized tubes. Aliquots of 10 μL or larger are recommended.
Expédition	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stabilité et stockage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Noms alternatifs	Neurotrophic tyrosine kinase, receptor-related 1, Inactive tyrosine-protein kinase transmembrane receptor ROR1, NTRKR1, ROR1
Contexte	Inactive tyrosine-protein kinase transmembrane receptor ROR1 (NTRKR1) is a ~104 kDa protein. Has very low kinase activity in vitro and is unlikely to function as a tyrosine kinase in vivo. Receptor for ligand WNT5A which activate downstream NFkB signaling pathway and may result in the inhibition of WNT3A-mediated signaling. In inner ear, crucial for spiral ganglion neurons to innervate auditory hair cells. Via IGFBP5 ligand, forms a complex with ERBB2 to enhance CREB oncogenic signaling. 1. Bainbridge, TW. et al. (2014) PloS one 9, e102695. PMID: 25029443 2. Diaz-Horta, O. et al. (2016) Proceedings of the National Academy of Sciences of the United States of America 113, 5993-8. PMID: 27162350 3. Lin, W. et al. (2023) Nature communications 14, 1578. PMID: 36949068
Note	For research use only.

Images

SDS-PAGE

SDS-PAGE for Recombinant Human ROR1 Protein, C-His
Bioactivity

Detects Zilovertamab in indirect ELISAs.
Bioactivity

Detects Mouse ROR1 Antibody (R11) in indirect ELISAs.
Bioactivity

Detected by Anti-Human ROR1/NTRKR1 Antibody (R12) in indirect ELISA.
Western blot

Detected by Anti-ROR1 monoclonal antibody (Catalog No: HX065016)
Western blot

Detected by Anti-ROR1 monoclonal antibody (Catalog No: HX065307)
Western blot

Detected by Anti-ROR1 monoclonal antibody (Catalog No: HX065307)
Bioactivity

Detected by Nebratamig (Catalog No: HC336146) in indirect ELISA.