Anti-Human ROR1 Reference Antibody (Zilovertamab, RUO) (HX065016)

Name: Anti-Human ROR1 Reference Antibody (Zilovertamab, RUO)
Brand: abinScience
SKU: HX065016
Price: 176 USD
Availability: InStock

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Overview
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References
Datasheet
SDS

Overview

Catalog No.	HX065016
Description	Zilovertamab (HX065016) is a research-grade recombinant antibody targeting Neurotrophic tyrosine kinase. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
Species reactivity	Human
Applications	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Host species	Human
Isotype	IgG1-Kappa
Expression system	Mammalian cells
Clonality	Monoclonal
Target	Neurotrophic tyrosine kinase, receptor-related 1, Inactive tyrosine-protein kinase transmembrane receptor ROR1, NTRKR1, ROR1
Endotoxin level	Please contact the lab for this information.
Purity	>95% purity as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	Q01973
Form	Liquid
Storage buffer	0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	cirmtuzumab, 2485779-13-1
Background	Inactive tyrosine-protein kinase transmembrane receptor ROR1 (NTRKR1) is a ~104 kDa protein. Has very low kinase activity in vitro and is unlikely to function as a tyrosine kinase in vivo. Receptor for ligand WNT5A which activate downstream NFkB signaling pathway and may result in the inhibition of WNT3A-mediated signaling. In inner ear, crucial for spiral ganglion neurons to innervate auditory hair cells. Via IGFBP5 ligand, forms a complex with ERBB2 to enhance CREB oncogenic signaling. 1. Bainbridge, TW. et al. (2014) PloS one 9, e102695. PMID: 25029443 2. Diaz-Horta, O. et al. (2016) Proceedings of the National Academy of Sciences of the United States of America 113, 5993-8. PMID: 27162350 3. Lin, W. et al. (2023) Nature communications 14, 1578. PMID: 36949068
Note	For research use only. Not suitable for clinical or therapeutic use.

Images

SEC-HPLC

SEC-HPLC detection for Research Grade Zilovertamab.
Bioactivity

Detects ROR1 in indirect ELISAs.
Western blot

Western blot analysis was performed using anti-ROR1 monoclonal antibody at 1ug/mL on various samples.
Lane 1: recombinant human ROR1 (Catalog No: HX065011)
Lane 2: negative control
SDS-PAGE

SDS-PAGE for Research Grade Zilovertamab