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| カタログ番号 | HP790022 |
|---|---|
| 説明 |
Recombinant Human TRPM4 Protein, N-His-SUMO (HP790022) expressed in E. coli. Purity: >90% as determined by SDS-PAGE..
Highlights
|
| 発現システム | E. coli |
| アクセッション番号 | Q8TD43 |
| タンパク質長 | Leu952-Leu1019 |
| アプリケーション | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 種 | Homo sapiens (Human) |
| 性質 | Recombinant |
| エンドトキシンレベル | Please contact with the lab for this information. |
| 純度 | >90% as determined by SDS-PAGE. |
| 形態 | Lyophilized |
| 保存バッファー | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
| 再構成 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 発送 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 別名 | Calcium-activated non-selective cation channel 1, LTRPC4, LTrpC-4, LTrpC4, Long transient receptor potential channel 4, Melastatin-4, TRPM4, Transient receptor potential cation channel subfamily M member 4, hTRPM4 |
| 背景 | Transient receptor potential cation channel subfamily M member 4 is a ~134 kDa protein. Calcium-activated selective cation channel that mediates membrane depolarization. While it is activated by increase in intracellular Ca(2+), it is impermeable to it. Mediates transport of monovalent cations (Na(+) > K(+) > Cs(+) > Li(+)), leading to depolarize the membrane. It thereby plays a central role in cadiomyocytes, neurons from entorhinal cortex, dorsal root and vomeronasal neurons, endocrine pancreas cells, kidney epithelial cells, cochlea hair cells etc. Participates in T-cell activation by modulating Ca(2+) oscillations after T lymphocyte activation, which is required for NFAT-dependent IL2 production. 1. Launay, P. et al. (2002) Cell 109, 397-407. PMID: 12015988 2. Hofmann, T. et al. (2003) Current biology : CB 13, 1153-8. PMID: 12842017 3. Winkler, PA. et al. (2017) Nature 552, 200-204. PMID: 29211723 4. Wang, H. et al. (2019) The Journal of investigative dermatology 139, 1089-1097. PMID: 30528822 |
| 注意事項 | For research use only |
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