Anti-Human TRPM4/LTRPC4 Polyclonal Antibody (HP790014)

Name: Anti-Human TRPM4/LTRPC4 Polyclonal Antibody
Brand: abinScience
SKU: HP790014
Price: 168 USD
Availability: InStock

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References
Datasheet
SDS

Overview

Catalog No.

HP790014

Description

Anti-Human TRPM4/LTRPC4 Polyclonal Antibody (HP790014) is a rabbit polyclonal antibody detecting LTRPC4 in ELISA, WB. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.

Species reactivity

Human

Applications

ELISA, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

Synthetic peptides.

Target

LTRPC4, Transient receptor potential cation channel subfamily M member 4, TRPM4, Melastatin-4, LTrpC-4, hTRPM4, Calcium-activated non-selective cation channel 1, LTrpC4, Long transient receptor potential channel 4

Endotoxin level

Please contact with the lab for this information.

Purification

Purified by antigen affinity column.

Accession

Q8TD43

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Transient receptor potential cation channel subfamily M member 4 (TRPM4/LTRPC4) is a ~134 kDa protein. Calcium-activated selective cation channel that mediates membrane depolarization. While it is activated by increase in intracellular Ca(2+), it is impermeable to it. Mediates transport of monovalent cations (Na(+) > K(+) > Cs(+) > Li(+)), leading to depolarize the membrane. It thereby plays a central role in cadiomyocytes, neurons from entorhinal cortex, dorsal root and vomeronasal neurons, endocrine pancreas cells, kidney epithelial cells, cochlea hair cells etc. Participates in T-cell activation by modulating Ca(2+) oscillations after T lymphocyte activation, which is required for NFAT-dependent IL2 production.

1. Launay, P. et al. (2002) Cell 109, 397-407. PMID: 12015988

2. Hofmann, T. et al. (2003) Current biology : CB 13, 1153-8. PMID: 12842017

3. Winkler, PA. et al. (2017) Nature 552, 200-204. PMID: 29211723

4. Wang, H. et al. (2019) The Journal of investigative dermatology 139, 1089-1097. PMID: 30528822

Note

For research use only.

Images

References

Datasheet

Anti-Human TRPM4/LTRPC4 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

Assay Kits

Anti-Human TRPM4/LTRPC4 Polyclonal Antibody (HP790014)

Overview

Images

References

Datasheet

SDS

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