Anti-Human TRPM4/LTRPC4 Recombinant Antibody (SAA0760) (HP790013)

Name: Anti-Human TRPM4/LTRPC4 Recombinant Antibody (SAA0760)
Brand: abinScience
SKU: HP790013
Price: 126 USD
Availability: InStock

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Overview
Images
References
Datasheet
SDS

Overview

Catalog No.

HP790013

Description

Anti-Human TRPM4/LTRPC4 Recombinant Antibody (SAA0760) (HP790013) is a human monoclonal antibody detecting TRPM4/LTRPC4 in ELISA, WB. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

Species reactivity

Human

Applications

ELISA, WB

Host species

Human

Clonality

Monoclonal

Isotype

VHH-hFc

Clone ID

SAA0760

Tested applications

Target

LTRPC4, Transient receptor potential cation channel subfamily M member 4, TRPM4, Melastatin-4, LTrpC-4, hTRPM4, Calcium-activated non-selective cation channel 1, LTrpC4, Long transient receptor potential channel 4

Endotoxin level

< 10 EU/mg as determined by LAL method.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

Q8TD43

RRID

Anti-Human TRPM4/LTRPC4 Antibody (SAA0760) (abinScience Cat# HP790013, RRID:AB_3726306)
_x005F_x000D_

Form

Liquid

Storage buffer

0.01M PBS pH 7.4.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:2000-1:20000
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Background

Transient receptor potential cation channel subfamily M member 4 (TRPM4/LTRPC4) is a ~134 kDa protein. Calcium-activated selective cation channel that mediates membrane depolarization. While it is activated by increase in intracellular Ca(2+), it is impermeable to it. Mediates transport of monovalent cations (Na(+) > K(+) > Cs(+) > Li(+)), leading to depolarize the membrane. It thereby plays a central role in cadiomyocytes, neurons from entorhinal cortex, dorsal root and vomeronasal neurons, endocrine pancreas cells, kidney epithelial cells, cochlea hair cells etc. Participates in T-cell activation by modulating Ca(2+) oscillations after T lymphocyte activation, which is required for NFAT-dependent IL2 production.

1. Launay, P. et al. (2002) Cell 109, 397-407. PMID: 12015988

2. Hofmann, T. et al. (2003) Current biology : CB 13, 1153-8. PMID: 12842017

3. Winkler, PA. et al. (2017) Nature 552, 200-204. PMID: 29211723

4. Wang, H. et al. (2019) The Journal of investigative dermatology 139, 1089-1097. PMID: 30528822

Note

For research use only.

Images

Western blot

Western blot analysis was performed using anti-TRPM4 polyclonal antibody at 1μg/ml on various samples.
Lane 1: Jurkat cell lysate
Lane 2: PC12 cell lysate
Lane 3: Rat brain lysate
Western blot

Western blot analysis was performed using anti-TRPM4 polyclonal antibody at 1μg/ml on various samples.
Lane 1: Jurkat cell lysate
Lane 2: PC12 cell lysate
Lane 3: 23T cell lysate

References

Datasheet

Anti-Human TRPM4/LTRPC4 Recombinant Antibody (SAA0760).pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

Assay Kits

Anti-Human TRPM4/LTRPC4 Recombinant Antibody (SAA0760) (HP790013)

Overview

Images

References

Datasheet

SDS