Anti-Human Endoglin/CD105 Reference Antibody (TRC205, RUO) (HB604026)

Name: Anti-Human Endoglin/CD105 Reference Antibody (TRC205, RUO)
Brand: abinScience
SKU: HB604026
Price: 370 USD
Availability: InStock

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Número de catálogo	HB604026
Descripción	Anti-Human CD105/ENG (TRC205) (HB604026) is a research-grade recombinant antibody targeting CD105. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
Reactividad de especies	Human
Aplicaciones	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Especie huésped	Human
Clonalidad	Monoclonal
Isotipo	IgG
ID de clon	TRC205
Sistema de expresión	Mammalian cells
Objetivo	CD105, END, Endoglin, ENG
Nivel de endotoxinas	< 10 EU/mg
Pureza	>95% purity as determined by SDS-PAGE.
Purificación	Protein A/G purified from cell culture supernatant.
Número de acceso	P17813
Forma	Liquid
Buffer de almacenamiento	0.01M PBS pH 7.4 Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Estabilidad y almacenamiento	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Nombres alternativos	TRC205
Fondo	Endoglin (CD105/ENG) is a ~70 kDa protein. Vascular endothelium glycoprotein that plays an important role in the regulation of angiogenesis. Required for normal structure and integrity of adult vasculature. Regulates the migration of vascular endothelial cells. Required for normal extraembryonic angiogenesis and for embryonic heart development. May regulate endothelial cell shape changes in response to blood flow, which drive vascular remodeling and establishment of normal vascular morphology during angiogenesis. 1. Castonguay, R. et al. (2011) The Journal of biological chemistry 286, 30034-46. PMID: 21737454 2. Nolan-Stevaux, O. et al. (2012) PloS one 7, e50920. PMID: 23300529 3. McAllister, KA. et al. (1994) Nature genetics 8, 345-51. PMID: 7894484 4. Lee, NY. et al. (2007) The Journal of biological chemistry 282, 21507-17. PMID: 17540773 5. Gougos, A. et al. (1990) The Journal of biological chemistry 265, 8361-4. PMID: 1692830 6. Alt, A. et al. (2012) PloS one 7, e29948. PMID: 22347366 7. Bellón, T. et al. (1993) European journal of immunology 23, 2340-5. PMID: 8370410
Nota	For research use only. Not suitable for clinical or therapeutic use.