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| カタログ番号 | HP700046 |
|---|---|
| 説明 |
Research Grade Anti-Human CD112/Nectin-2/PVRL2 Antibody (NTX-1107C) [NTX-1107C] (HP700046) is a mouse monoclonal antibody detecting Nectin-2 in ELISA, Bioactivity: FACS, Functional assay, Research in vivo. Suitable for Human.
Highlights
|
| 種反応性 | Human |
| アプリケーション | ELISA, Bioactivity: FACS, Functional assay, Research in vivo |
| 宿主種 | Mouse |
| クローン性 | Monoclonal |
| アイソタイプ | IgG2a, kappa |
| クローンID | NTX-1107C |
| ターゲット | Nectin-2, Herpes virus entry mediator B, Herpesvirus entry mediator B, HveB, Nectin cell adhesion molecule 2, Poliovirus receptor-related protein 2, CD112, NECTIN2, HVEB, PRR2, PVRL2 |
| エンドトキシンレベル | < 10 EU/mg |
| 純度 | >95% as determined by SDS-PAGE. |
| 精製 | Protein A/G purified from cell culture supernatant. |
| アクセッション番号 | Q92692 |
| 形態 | Liquid |
| 保存バッファー | 0.01M PBS pH 7.4 データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 背景 | Nectin-2 (CD112/PVRL2) is a ~57 kDa protein. Modulator of T-cell signaling. Can be either a costimulator of T-cell function, or a coinhibitor, depending on the receptor it binds to. Upon binding to CD226, stimulates T-cell proliferation and cytokine production, including that of IL2, IL5, IL10, IL13, and IFNG. Upon interaction with PVRIG, inhibits T-cell proliferation. These interactions are competitive. 1. Zhu, Y. et al. (2016) The Journal of experimental medicine 213, 167-76. PMID: 26755705 2. Warner, MS. et al. (1998) Virology 246, 179-89. PMID: 9657005 |
| 注意事項 | For research use only. |
| Isotype Control | Mouse IgG2a (Fc Silence) Recombinant Isotype Control (MOPC 173) (MF533023) |
SDS-PAGE for Anti-Human CD112/Nectin-2/PVRL2 Reference Antibody (NTX-1107C, RUO)
Detects recombinant human CD112/Nectin-2/PVRL2 (Catalog No: HV456011) in indirect ELISA
Western blot analysis was performed using anti-CD112/Nectin-2/PVRL2 monoclonal antibody at 1ug/mL on various samples.
Lane 1: recombinant human CD112/Nectin-2/PVRL2 (Catalog No: HV456011)
Lane 2: negative control
Lane 3: negative control
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