Anti-Human CD112/Nectin-2/PVRL2 Recombinant Antibody (SAA2115) (HV456207)

Name: Anti-Human CD112/Nectin-2/PVRL2 Recombinant Antibody (SAA2115)
Brand: abinScience
SKU: HV456207
Price: 196 USD
Availability: InStock

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Overview

Catalog No.	HV456207
Species reactivity	Human
Applications	FCM, WB
Host species	Mouse
Isotype	IgG2a
Clone ID	SAA2115
Clonality	Monoclonal
Target	Nectin-2, Herpes virus entry mediator B, Herpesvirus entry mediator B, HveB, Nectin cell adhesion molecule 2 receptor-related protein 2, CD112, NECTIN2, HVEB, PRR2, PVRL2
Endotoxin level	Please contact with the lab for this information.
Purity	>95% as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	Q92692
Form	Liquid
Storage buffer	0.01M PBS, pH 7.4, 0.09% Sodium azide. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Background	Nectin-2 (CD112/PVRL2) is a ~57 kDa protein. Modulator of T-cell signaling. Can be either a costimulator of T-cell function, or a coinhibitor, depending on the receptor it binds to. Upon binding to CD226, stimulates T-cell proliferation and cytokine production, including that of IL2, IL5, IL10, IL13, and IFNG. Upon interaction with PVRIG, inhibits T-cell proliferation. These interactions are competitive. 1. Zhu, Y. et al. (2016) The Journal of experimental medicine 213, 167-76. PMID: 26755705 2. Warner, MS. et al. (1998) Virology 246, 179-89. PMID: 9657005
Note	For research use only.

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SDS-PAGE

SDS-PAGE for Anti-Human CD112/Nectin-2/PVRL2 Antibody (SAA2115)
Bioactivity

Detects recombinant human CD112/Nectin-2/PVRL2 (Catalog No: HV456011) in indirect ELISA
Western blot

Western blot analysis was performed using anti-/ monoclonal antibody at 1ug/mL on various samples.
Lane 1: ATGE5545 200ng
Lane 2: 1* loading buffer

References

Datasheet

Anti-Human CD112/Nectin-2/PVRL2 Recombinant Antibody (SAA2115).pdf

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Anti-Human CD112/Nectin-2/PVRL2 Recombinant Antibody (SAA2115) (HV456207)

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