Anti-Human 4-1BB/TNFRSF9/CD137 Reference Antibody (CTX-471, RUO) (HC336036)

Name: Anti-Human 4-1BB/TNFRSF9/CD137 Reference Antibody (CTX-471, RUO)
Brand: abinScience
SKU: HC336036
Price: 346 USD
Availability: InStock

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Numéro de catalogue	HC336036
Description	Anti-Human 4-1BB/TNFRSF9/CD137 Reference Antibody (CTX-471, RUO) (HC336036) is a human monoclonal antibody detecting 4-1BB Ligand/TNFSF9.
Reactivité des espèces	Human
Applications	ELISA, Bioactivity: FCM, Functional assay, Research in vivo
Espèce hôte	Human
Clonalité	Monoclonal
Isotype	IgG
ID de clone	CTX-471
Activité biologique	CTX-471 (5-500 nM) has bind affinity for recombinant human, cynomolgus macaque CD137 and mouse CD137 with K d values of 50 nM, 61 nM and 748 nM, respectively [1]. CTX-471 binds to a unique epitope on CD137 [1]. CTX-471 (0.1-100 nM; 1, 10 ug/mL; 3 days) increases IFN-y production by human T cells in an Fcy receptor-dependent (FcyR-dependent) manner in vitro [1]. CTX-471 (i.p.; 150 ug) exhibits curative monotherapy activity in various syngeneic tumor models and shows a unique ability to cure mice of very large tumors. CTX-471 (i.v.; 10-80 mg/kg; on days 0, 7, 14, and 21) is well tolerated, with no signs of hepatic toxicity in high doses.
Cible	4-1BB ligand receptor, CD137, CDw137, ILA, T-cell antigen 4-1BB homolog, T-cell antigen ILA, TNFRSF9, Tumor necrosis factor receptor superfamily member 9
Niveau d'endotoxines	< 10 EU/mg
Pureté	>95% as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Numéro d'accès	Q07011
Forme	Liquid
Tampon de stockage	0.01M PBS pH 7.4. Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.
Stabilité et stockage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Noms alternatifs	CTX-471, CTX471, CTX471
Contexte	Tumor necrosis factor receptor superfamily member 9 (CD137/4-1BB) is a ~27 kDa protein. Receptor for TNFSF9/4-1BBL. Conveys a signal that enhances CD8(+) T-cell survival, cytotoxicity, and mitochondrial activity, thereby promoting immunity against viruses and tumors (Probable).
Reférences	1. Ugur Eskiocak, et al. Differentiated agonistic antibody targeting CD137 eradicates large tumors without hepatotoxicity. JCI Insight. 2020 Mar 12;5(5):e133647. [HC336036]
Note	For research use only. Not suitable for clinical or therapeutic use.