Anti-Human Coagulation factor III/Tissue Factor Reference Antibody (CNTO 860, RUO) (HB058036)

Name: Anti-Human Coagulation factor III/Tissue Factor Reference Antibody (CNTO 860, RUO)
Brand: abinScience
SKU: HB058036
Price: 326 USD
Availability: InStock

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Número de catálogo	HB058036
Reactividad de especies	Human
Aplicaciones	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Especie huésped	Human
Clonalidad	Monoclonal
Isotipo	IgG
ID de clon	CNTO 860
Sistema de expresión	Mammalian cells
Objetivo	Tissue factor, CD142, F3, Thromboplastin, Coagulation factor III, TF
Nivel de endotoxinas	< 10 EU/mg
Pureza	>95% purity as determined by SDS-PAGE.
Purificación	Protein A/G purified from cell culture supernatant.
Número de acceso	P13726
Forma	Liquid
Buffer de almacenamiento	0.01M PBS pH 7.4 Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Estabilidad y almacenamiento	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Nombres alternativos	CNTO-860, CNTO860, CNTO860
Fondo	Tissue factor (CD142/F3) is a ~33 kDa protein. Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade. CD142 is the therapeutic target of tisotumab vedotin (Tivdak).
Referencias	1. Richard S. Tawadros, et al., CNTO 860, a humanized anti-tissue factor monoclonal antibody, significantly improves tumor response to paclitaxel in a xenograft model of colon cancer. EXPERIMENTAL AND MOLECULAR THERAPEUTICS 20: ADVANCES IN CANCER THERAPEUTICS 2006. [HB058036]
Nota	For research use only. Not suitable for clinical or therapeutic use.