Anti-Human Coagulation factor III/Tissue Factor Reference Antibody (CNTO 860, RUO) (HB058036)

Name: Anti-Human Coagulation factor III/Tissue Factor Reference Antibody (CNTO 860, RUO)
Brand: abinScience
SKU: HB058036
Price: 326 USD
Availability: InStock

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Numéro de catalogue	HB058036
Reactivité des espèces	Human
Applications	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Espèce hôte	Human
Clonalité	Monoclonal
Isotype	IgG
ID de clone	CNTO 860
Système d'expression	Mammalian cells
Cible	Tissue factor, CD142, F3, Thromboplastin, Coagulation factor III, TF
Niveau d'endotoxines	< 10 EU/mg
Pureté	>95% purity as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Numéro d'accès	P13726
Forme	Liquid
Tampon de stockage	0.01M PBS pH 7.4 Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.
Stabilité et stockage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Noms alternatifs	CNTO-860, CNTO860, CNTO860
Contexte	Tissue factor (CD142/F3) is a ~33 kDa protein. Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade. CD142 is the therapeutic target of tisotumab vedotin (Tivdak).
Reférences	1. Richard S. Tawadros, et al., CNTO 860, a humanized anti-tissue factor monoclonal antibody, significantly improves tumor response to paclitaxel in a xenograft model of colon cancer. EXPERIMENTAL AND MOLECULAR THERAPEUTICS 20: ADVANCES IN CANCER THERAPEUTICS 2006. [HB058036]
Note	For research use only. Not suitable for clinical or therapeutic use.