Anti-Human FGFR4 Reference Antibody (U3-1784, RUO) (HB856016)

Name: Anti-Human FGFR4 Reference Antibody (U3-1784, RUO)
Brand: abinScience
SKU: HB856016
Price: 176 USD
Availability: InStock

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Aperçu
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Reférences
Fiche technique
SDS

Aperçu

Numéro de catalogue

HB856016

Description

Anti-Human CD334/FGFR4 (U3-1784) (HB856016) is a research-grade recombinant antibody targeting CD334. Produced in mammalian cells with native-like glycosylation.

Highlights

●Research Grade — For PK/PD studies, assay development, and ADA research.
●Native Glycosylation — Mammalian expression ensures native-like patterns.

Reactivité des espèces

Human

Applications

ELISA, Bioactivity: FACS, Functional assay, Research in vivo

Espèce hôte

Human

Clonalité

Monoclonal

Isotype

IgG1

ID de clone

U3-1784

Système d'expression

Mammalian cells

Cible

FGFR4, Fibroblast growth factor receptor 4, TKF, FGFR-4, JTK2, CD334

Niveau d'endotoxines

< 10 EU/mg

Pureté

>95% purity as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Numéro d'accès

P22455

Forme

Liquid

Tampon de stockage

0.01M PBS pH 7.4

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.

Informations d'utilisation du produit

Application	Dilution
ELISA	1:2000-1:20000

Stabilité et stockage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Noms alternatifs

U3-1784

Contexte

Fibroblast growth factor receptor 4 (CD334/FGFR4) is a ~87 kDa protein. Tyrosine-protein kinase that acts as a cell-surface receptor for fibroblast growth factors and plays a role in the regulation of cell proliferation, differentiation and migration, and in regulation of lipid metabolism, bile acid biosynthesis, glucose uptake, vitamin D metabolism and phosphate homeostasis. Required for normal down-regulation of the expression of CYP7A1, the rate-limiting enzyme in bile acid synthesis, in response to FGF19. Phosphorylates PLCG1 and FRS2. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate.

Note

For research use only. Not suitable for clinical or therapeutic use.

Isotype Control

Human IgG1, lambda Isotype Control antibody (HyHEL-10) (HP248107)

Images

SDS-PAGE

SDS-PAGE for Anti-Human FGFR4 Reference Antibody (U3-1784, RUO)

Reférences

Fiche technique

Anti-Human FGFR4 Reference Antibody (U3-1784, RUO).pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Protéines Recombinantes

Anticorps

Kits d'Essai