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Anti-Human GITR/TNFRSF18 Reference Antibody (AMG 228, RUO) (HP087026)

Anti-Human GITR/TNFRSF18 Reference Antibody (AMG 228, RUO)
Anti-Human GITR/TNFRSF18 Reference Antibody (AMG 228, RUO)
Anti-Human GITR/TNFRSF18 Reference Antibody (AMG 228, RUO)
Anti-Human GITR/TNFRSF18 Reference Antibody (AMG 228, RUO)
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Спецификация:
  • 100ug
  • 1mg
  • 5mg
  • 10mg
  • 25mg
  • 50mg
  • 100mg
Количество:
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  • Даташит

  • SDS

Обзор
Каталожный номерHP087026
Реактивность видовHuman
ПримененияELISA, Bioactivity: FACS, Functional assay, Research in vivo
Хозяинский видHuman
КлоональностьMonoclonal
ИзотипIgG
ID клонаAMG 228
Система экспрессии Mammalian cells
Цель Activation-inducible TNFR family receptor, GITR, TNFRSF18, CD357, Tumor necrosis factor receptor superfamily member 18, AITR, Glucocorticoid-induced TNFR-related protein
Уровень эндотоксинов < 10 EU/mg
Чистота >95% purity as determined by SDS-PAGE.
Очистка Protein A/G purified from cell culture supernatant.
Номер доступа Q9Y5U5
Форма Liquid
Буфер хранения 0.01M PBS pH 7.4

Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.

Устойчивость и хранение Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Альтернативные названияAMG-228, AMG228, AMG228
Фон

Tumor necrosis factor receptor superfamily member 18 (CD357/GITR) is a ~26 kDa protein. Receptor for TNFSF18. Seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. Mediated NF-kappa-B activation via the TRAF2/NIK pathway.

Ссылки 1. Tran B, et al. Dose escalation results from a first-in-human, phase 1 study of glucocorticoid-induced TNF receptor-related protein agonist AMG 228 in patients with advanced solid tumors. J Immunother Cancer. 2018 Sep 25;6(1):93. [HP087026]
Примечание For research use only. Not suitable for clinical or therapeutic use.
Isotype Control Human IgG1 Recombinant Isotype Control Antibody (13R4) (HV080507)
Изображения
  • Anti-Human GITR/TNFRSF18 Reference Antibody (AMG 228, RUO)

    SDS-PAGE

    SDS-PAGE for Research Grade Anti-Human CD357/TNFRSF18/GITR (AMG 228)

  • Anti-Human GITR/TNFRSF18 Reference Antibody (AMG 228, RUO)

    Bioactivity

    Detects recombinant human CD357/TNFRSF18/GITR (Catalog No: HV475012) in indirect ELISA

Ссылки
Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
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Formula
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Stock Solution
C₁ (Stock Conc.)
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V₁ (Stock Vol.)
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Working Solution
C₂ (Working Conc.)
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