Research Grade Efgivanermin Alfa (HV475036)

Name: Research Grade Efgivanermin Alfa
Brand: abinScience
SKU: HV475036
Price: 424 USD
Availability: InStock

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Overview

Catalog No.	HV475036
Description	Efgivanermin Alfa (HV475036) is a research-grade recombinant antibody targeting CD357. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
Species reactivity	Human
Applications	ELISA, Functional assay, Research in vivo
Isotype	Fusion - [IGHG1 Fc (Fragment constant) - [CORO1A (coronin 1A, actin-binding protein) - TNFSF18 (TNF superfamily member 18, AITRL, TL6, GITRL)]2]3 (hexamer)
Expression system	Mammalian cells
Target	Activation-inducible TNFR family receptor, GITR, TNFRSF18, CD357, Tumor necrosis factor receptor superfamily member 18, AITR, Glucocorticoid-induced TNFR-related protein
Endotoxin level	Please contact the lab for this information.
Purity	>95% purity as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	Q9Y5U5
Form	Liquid
Storage buffer	0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	MEDI-1873, MEDI1873, 1807864-13-6
Background	Tumor necrosis factor receptor superfamily member 18 (CD357/GITR) is a ~26 kDa protein. Receptor for TNFSF18. Seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. Mediated NF-kappa-B activation via the TRAF2/NIK pathway.
Note	For research use only. Not suitable for clinical or therapeutic use.