Anti-Human GITR/TNFRSF18 Reference Antibody (FPA154, RUO) (HV475066)

Name: Anti-Human GITR/TNFRSF18 Reference Antibody (FPA154, RUO)
Brand: abinScience
SKU: HV475066
Price: 370 USD
Availability: InStock

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Número de catálogo	HV475066
Descripción	Anti-Human GITR/TNFRSF18 Reference Antibody (FPA154, RUO) (HV475066) is a human monoclonal antibody detecting GITR/TNFRSF18. Expressed in Mammalian cells.
Reactividad de especies	Human
Aplicaciones	ELISA, Bioactivity: FCM, Functional assay, Research in vivo
Especie huésped	Human
Clonalidad	Monoclonal
Isotipo	IgG
ID de clon	FPA154
Actividad biológica	FPA154 can potently exert antibody-dependent cell-mediated cytotoxicity against regulatory T cells that highly express GITR [1].
Sistema de expresión	Mammalian cells
Naturaleza	Recombinant
Objetivo	Activation-inducible TNFR family receptor, GITR, TNFRSF18, CD357, Tumor necrosis factor receptor superfamily member 18, AITR, Glucocorticoid-induced TNFR-related protein
Nivel de endotoxinas	< 10 EU/mg as determined by LAL method.
Pureza	>95% as determined by SDS-PAGE.
Purificación	Protein A/G purified from cell culture supernatant.
Número de acceso	Q9Y5U5
Forma	Liquid
Buffer de almacenamiento	0.01M PBS pH 7.4. Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Estabilidad y almacenamiento	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Nombres alternativos	FPA154
Fondo	Tumor necrosis factor receptor superfamily member 18 (CD357/GITR) is a ~26 kDa protein. Receptor for TNFSF18. Seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. Mediated NF-kappa-B activation via the TRAF2/NIK pathway.
Referencias	1. Susannah D. Barbee, et al. Abstract 613: Development of FPA154, a novel tetravalent anti-GITR antibody, for the treatment of solid tumors. Cancer Res 1 July 2017; 77 (13_Supplement): 613. [HV475066]
Nota	For research use only. Not suitable for clinical or therapeutic use.

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SDS-PAGE

SDS-PAGE for Research Grade Anti-Human CD357/TNFRSF18/GITR (FPA154)

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Datasheet

Anti-Human GITR/TNFRSF18 Reference Antibody (FPA154, RUO).pdf

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Formula

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Anti-Human GITR/TNFRSF18 Reference Antibody (FPA154, RUO) (HV475066)

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Referencias

Datasheet

SDS