

| Каталожный номер | HV475066 |
|---|---|
| Описание |
Anti-Human GITR/TNFRSF18 Reference Antibody (FPA154, RUO) (HV475066) is a human monoclonal antibody detecting GITR/TNFRSF18. Expressed in Mammalian cells.
|
| Реактивность видов | Human |
| Применения | ELISA, Bioactivity: FCM, Functional assay, Research in vivo |
| Хозяинский вид | Human |
| Клоональность | Monoclonal |
| Изотип | IgG |
| ID клона | FPA154 |
| Биологическая активность | FPA154 can potently exert antibody-dependent cell-mediated cytotoxicity against regulatory T cells that highly express GITR [1]. |
| Система экспрессии | Mammalian cells |
| Характер | Recombinant |
| Цель | Activation-inducible TNFR family receptor, GITR, TNFRSF18, CD357, Tumor necrosis factor receptor superfamily member 18, AITR, Glucocorticoid-induced TNFR-related protein |
| Уровень эндотоксинов | < 10 EU/mg as determined by LAL method. |
| Чистота | >95% as determined by SDS-PAGE. |
| Очистка | Protein A/G purified from cell culture supernatant. |
| Номер доступа | Q9Y5U5 |
| Форма | Liquid |
| Буфер хранения | 0.01M PBS pH 7.4. Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии. |
| Устойчивость и хранение | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| Альтернативные названия | FPA154 |
| Фон | Tumor necrosis factor receptor superfamily member 18 (CD357/GITR) is a ~26 kDa protein. Receptor for TNFSF18. Seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. Mediated NF-kappa-B activation via the TRAF2/NIK pathway. |
| Ссылки | 1. Susannah D. Barbee, et al. Abstract 613: Development of FPA154, a novel tetravalent anti-GITR antibody, for the treatment of solid tumors. Cancer Res 1 July 2017; 77 (13_Supplement): 613. [HV475066] |
| Примечание | For research use only. Not suitable for clinical or therapeutic use. |

SDS-PAGE for Research Grade Anti-Human CD357/TNFRSF18/GITR (FPA154)




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