Anti-Human TIM-1/KIM-1/HAVCR Reference Antibody (CDX 014, RUO) (HV277016)

Name: Anti-Human TIM-1/KIM-1/HAVCR Reference Antibody (CDX 014, RUO)
Brand: abinScience
SKU: HV277016
Price: 326 USD
Availability: InStock

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Обзор

Каталожный номер	HV277016
Описание	Anti-Human CD365/KIM-1/TIM-1/HAVCR1 (CDX 014) (HV277016) is a research-grade recombinant antibody targeting CD365. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
Реактивность видов	Human
Применения	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Хозяинский вид	Human
Клоональность	Monoclonal
Изотип	IgG
ID клона	CDX 014
Система экспрессии	Mammalian cells
Цель	TIM, Kidney injury molecule 1, T-cell immunoglobulin mucin receptor 1, KIM1, KIM-1, TIM1, TIMD1, HAVCR1, T-cell immunoglobulin and mucin domain-containing protein 1, T-cell membrane protein 1, CD365, Hepatitis A virus cellular receptor 1, HAVcr-1, TIMD-1, TIM-1
Уровень эндотоксинов	< 10 EU/mg
Чистота	>95% purity as determined by SDS-PAGE.
Очистка	Protein A/G purified from cell culture supernatant.
Номер доступа	Q96D42
Форма	Liquid
Буфер хранения	0.01M PBS pH 7.4 Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.
Устойчивость и хранение	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Альтернативные названия	CDX-014, CDX014, CDX014
Фон	Hepatitis A virus cellular receptor 1 (CD365/KIM-1) is a ~39 kDa protein. Phosphatidylserine receptor that plays an important functional role in regulatory B-cell homeostasis including generation, expansion and suppressor functions. As P-selectin/SELPLG ligand, plays a specialized role in activated but not naive T-cell trafficking during inflammatory responses. Controls thereby T-cell accumulation in the inflamed central nervous system (CNS) and the induction of autoimmune disease. Also regulates expression of various anti-inflammatory cytokines and co-inhibitory ligands including IL10. Acts as a regulator of T-cell proliferation. 1. Angiari, S. et al. (2014) Immunity 40, 542-53. PMID: 24703780 2. Ichimura, T. et al. (2008) The Journal of clinical investigation 118, 1657-68. PMID: 18414680
Примечание	For research use only. Not suitable for clinical or therapeutic use.

Изображения

SDS-PAGE

SDS-PAGE for Research Grade Anti-Human CD365/KIM-1/TIM-1/HAVCR1 (CDX 014)

Ссылки

Даташит

Anti-Human TIM-1/KIM-1/HAVCR Reference Antibody (CDX 014, RUO).pdf

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