Anti-Human Enolase 1/ENO1 Reference Antibody (HuL001, RUO) (HY081016)

Name: Anti-Human Enolase 1/ENO1 Reference Antibody (HuL001, RUO)
Brand: abinScience
SKU: HY081016
Price: 370 USD
Availability: InStock

Datasheet Compartir producto Copiar información

Precio(USD):

Especificación:

100ug
1mg
5mg
10mg
25mg
50mg
100mg

Número:

Contáctenos

Vista general
Imágenes
Referencias
Datasheet
SDS

Vista general

Número de catálogo	HY081016
Reactividad de especies	Human
Aplicaciones	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Especie huésped	Human
Clonalidad	Monoclonal
Isotipo	IgG
ID de clon	HuL001
Actividad biológica	HuL001 inhibits cancer-associated fibroblast-mediated tumor progression in a bortezomib ()-resistant multiple myeloma xenograft model [2].
Sistema de expresión	Mammalian cells
Objetivo	Non-neural enolase, 2-phospho-D-glycerate hydro-lyase, MPB-1, ENO1, Plasminogen-binding protein, Enolase 1, C-myc promoter-binding protein, Alpha-enolase, MBP-1, MBPB1, MPB1, ENO1L1, NNE, Phosphopyruvate hydratase
Nivel de endotoxinas	< 10 EU/mg
Pureza	>95% purity as determined by SDS-PAGE.
Purificación	Protein A/G purified from cell culture supernatant.
Número de acceso	P06733
Forma	Liquid
Buffer de almacenamiento	0.01M PBS pH 7.4 Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Estabilidad y almacenamiento	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Nombres alternativos	HuL001
Fondo	Alpha-enolase (ENO1) is a ~47 kDa protein. Enolase that catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate in glycolysis and the reverse reaction in gluconeogenesis. Also involved in various processes such as growth control, hypoxia tolerance and allergic responses. May also function in the intravascular and pericellular fibrinolytic system due to its ability to serve as a receptor and activator of plasminogen on the cell surface of several cell-types such as leukocytes and neurons. Stimulates immunoglobulin production. 1. Sugahara, T. et al. (1992) Cytotechnology 10, 137-46. PMID: 1369209 2. Huang, H. et al. (2018) Molecular cell 70, 663-678.e6. PMID: 29775581 3. Feo, S. et al. (2000) FEBS letters 473, 47-52. PMID: 10802057 4. López-Alemany, R. et al. (2003) American journal of hematology 72, 234-42. PMID: 12666133 5. Ray, R. et al. (1991) Molecular and cellular biology 11, 2154-61. PMID: 2005901
Referencias	1. Chao, K.S.C. et al. Tilting Immunometabolic Balance of Tumor Microenvironment by Targeting ENO1 in KRAS-Mutated Colorectal and Pancreatic Cancers. International Journal of Radiation Oncology, Biology, Physics, Volume 120, Issue 2, S97 [HY081016] 2. Maisie Huang, et al. Abstract LB067: Extracellular enolase-1 drives cancer-associated fibroblast differentiation in the tumor microenvironment to enhance tumor growth of multiple myeloma: Development of the therapeutic antibody, HuL001. Cancer Res 15 April 2025; 85 (8_Supplement_2): LB067. [HY081016]
Nota	For research use only. Not suitable for clinical or therapeutic use.