Anti-Human Enolase 1/ENO1 Reference Antibody (HuL001, RUO) (HY081016)

Name: Anti-Human Enolase 1/ENO1 Reference Antibody (HuL001, RUO)
Brand: abinScience
SKU: HY081016
Price: 370 USD
Availability: InStock

データシート製品共有情報コピー

価格(USD):

スペック:

100ug
1mg
5mg
10mg
25mg
50mg
100mg

数量:

お問い合わせ

概要
イメージ
参考文献
データシート
SDS

概要

カタログ番号	HY081016
種反応性	Human
アプリケーション	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
宿主種	Human
クローン性	Monoclonal
アイソタイプ	IgG
クローンID	HuL001
生物学的活性	HuL001 inhibits cancer-associated fibroblast-mediated tumor progression in a bortezomib ()-resistant multiple myeloma xenograft model [2].
発現システム	Mammalian cells
ターゲット	Non-neural enolase, 2-phospho-D-glycerate hydro-lyase, MPB-1, ENO1, Plasminogen-binding protein, Enolase 1, C-myc promoter-binding protein, Alpha-enolase, MBP-1, MBPB1, MPB1, ENO1L1, NNE, Phosphopyruvate hydratase
エンドトキシンレベル	< 10 EU/mg
純度	>95% purity as determined by SDS-PAGE.
精製	Protein A/G purified from cell culture supernatant.
アクセッション番号	P06733
形態	Liquid
保存バッファー	0.01M PBS pH 7.4 データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。
安定性と保存	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
別名	HuL001
背景	Alpha-enolase (ENO1) is a ~47 kDa protein. Enolase that catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate in glycolysis and the reverse reaction in gluconeogenesis. Also involved in various processes such as growth control, hypoxia tolerance and allergic responses. May also function in the intravascular and pericellular fibrinolytic system due to its ability to serve as a receptor and activator of plasminogen on the cell surface of several cell-types such as leukocytes and neurons. Stimulates immunoglobulin production. 1. Sugahara, T. et al. (1992) Cytotechnology 10, 137-46. PMID: 1369209 2. Huang, H. et al. (2018) Molecular cell 70, 663-678.e6. PMID: 29775581 3. Feo, S. et al. (2000) FEBS letters 473, 47-52. PMID: 10802057 4. López-Alemany, R. et al. (2003) American journal of hematology 72, 234-42. PMID: 12666133 5. Ray, R. et al. (1991) Molecular and cellular biology 11, 2154-61. PMID: 2005901
参考文献	1. Chao, K.S.C. et al. Tilting Immunometabolic Balance of Tumor Microenvironment by Targeting ENO1 in KRAS-Mutated Colorectal and Pancreatic Cancers. International Journal of Radiation Oncology, Biology, Physics, Volume 120, Issue 2, S97 [HY081016] 2. Maisie Huang, et al. Abstract LB067: Extracellular enolase-1 drives cancer-associated fibroblast differentiation in the tumor microenvironment to enhance tumor growth of multiple myeloma: Development of the therapeutic antibody, HuL001. Cancer Res 15 April 2025; 85 (8_Supplement_2): LB067. [HY081016]
注意事項	For research use only. Not suitable for clinical or therapeutic use.