Anti-Human Fibronectin Reference Antibody (HuBC-1-hIL12, RUO) (HY259026)

Name: Anti-Human Fibronectin Reference Antibody (HuBC-1-hIL12, RUO)
Brand: abinScience
SKU: HY259026
Price: 370 USD
Availability: InStock

データシート製品共有情報コピー

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100ug
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概要
イメージ
参考文献
データシート
SDS

概要

カタログ番号

HY259026

種反応性

Human

アプリケーション

ELISA, Bioactivity: FACS, Functional assay, Research in vivo

宿主種

Human

クローン性

Monoclonal

アイソタイプ

IgG1-hIL12, kappa

クローンID

HuBC-1-hIL12

生物学的活性

Fibronectin (FN) is a glycoprotein present in blood as well as in cells. While Fibronectin (FN) in blood has many functions, its primary role is to promote wound repair following injury [1]. Fibronectin also binds to other extracellular matrix proteins such as collagen, fibrin, and heparan sulfate proteoglycans (e.g. syndecans) [2].

発現システム

Mammalian cells

ターゲット

EDB, Cold-insoluble globulin, CIG, FN, Fibronectin, FN1

エンドトキシンレベル

< 10 EU/mg

純度

>95% purity as determined by SDS-PAGE.

精製

Protein A/G purified from cell culture supernatant.

アクセッション番号

P02751

形態

Liquid

保存バッファー

0.01M PBS pH 7.4

データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。

製品使用情報

アプリケーション	希釈
ELISA	1:2000-1:20000

安定性と保存

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

別名

HuBC-1ScFv, AS1409, hubc1, bc-1, bc1

背景

Fibronectin (FN) is a ~272 kDa protein. Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization. Participates in the regulation of type I collagen deposition by osteoblasts. Acts as a ligand for the LILRB4 receptor, inhibiting FCGR1A/CD64-mediated monocyte activation.

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1. Owens, RJ. et al. (1986) The EMBO journal 5, 2825-30. PMID: 3024962

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2. Garcia-Pardo, A. et al. (1987) The Biochemical journal 241, 923-8. PMID: 3593230

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3. Calaycay, J. et al. (1985) The Journal of biological chemistry 260, 12136-41. PMID: 3900070

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4. Rostagno, A. et al. (1994) The Journal of biological chemistry 269, 31938-45. PMID: 7989369

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5. Su, MT. et al. (2021) International immunology 33, 447-458. PMID: 34089617

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参考文献

1. Yuan-Wan Sun, et al. Effects of E-Cigarette Aerosols with Varying Levels of Nicotine on Biomarkers of Oxidative Stress and Inflammation in Mice. Chem Res Toxicol. 2021 Apr 19;34(4):1161-1168. [HY259026]
2. Roumen Pankov, et al. Fibronectin at a glance. J Cell Sci. 2002 Oct 15;115(Pt 20):3861-3. [HY259026]

注意事項

For research use only. Not suitable for clinical or therapeutic use.

イメージ

参考文献

データシート

Anti-Human Fibronectin Reference Antibody (HuBC-1-hIL12, RUO).pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

組換えタンパク質

抗体

アッセイキット

Anti-Human Fibronectin Reference Antibody (HuBC-1-hIL12, RUO) (HY259026)

概要

イメージ

参考文献

データシート

SDS

クイックアクセス

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