Anti-Human Fibronectin Reference Antibody (Micvotabart, RUO) (HY259066)

Name: Anti-Human Fibronectin Reference Antibody (Micvotabart, RUO)
Brand: abinScience
SKU: HY259066
Price: 176 USD
Availability: InStock

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SDS

Overview

Catalog No.	HY259066
Species reactivity	Human
Applications	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Host species	Human
Isotype	IgG1-kappa
Biological activity	Fibronectin (FN) is a glycoprotein present in blood as well as in cells. While Fibronectin (FN) in blood has many functions, its primary role is to promote wound repair following injury [1]. Fibronectin also binds to other extracellular matrix proteins such as collagen, fibrin, and heparan sulfate proteoglycans (e.g. syndecans) [2].
Expression system	Mammalian cells
Clonality	Monoclonal
Target	Cold-insoluble globulin, CIG, FN, Fibronectin, FN1
Endotoxin level	Please contact the lab for this information.
Purity	>95% purity as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	P02751
Form	Liquid
Storage buffer	0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	2867549-73-1
Background	Fibronectin (EDB) is a ~272 kDa protein. Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization. Participates in the regulation of type I collagen deposition by osteoblasts. Acts as a ligand for the LILRB4 receptor, inhibiting FCGR1A/CD64-mediated monocyte activation. 1. Owens, RJ. et al. (1986) The EMBO journal 5, 2825-30. PMID: 3024962 2. Garcia-Pardo, A. et al. (1987) The Biochemical journal 241, 923-8. PMID: 3593230 3. Calaycay, J. et al. (1985) The Journal of biological chemistry 260, 12136-41. PMID: 3900070 4. Rostagno, A. et al. (1994) The Journal of biological chemistry 269, 31938-45. PMID: 7989369 5. Su, MT. et al. (2021) International immunology 33, 447-458. PMID: 34089617
References	1. Yuan-Wan Sun, et al. Effects of E-Cigarette Aerosols with Varying Levels of Nicotine on Biomarkers of Oxidative Stress and Inflammation in Mice. Chem Res Toxicol. 2021 Apr 19;34(4):1161-1168. [HY259066] 2. Roumen Pankov, et al. Fibronectin at a glance. J Cell Sci. 2002 Oct 15;115(Pt 20):3861-3. [HY259066]
Note	For research use only. Not suitable for clinical or therapeutic use.

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SDS-PAGE

SDS-PAGE for Research Grade Micvotabart.
Bioactivity

Detects recombinant FN1 (Catalog No: HY259032) in indirect ELISA.
Western blot

Lane 1: recombinant human FN1 (Catalog No: HY259032)
Lane 2: 1*loading buffer

References

Datasheet

Anti-Human Fibronectin Reference Antibody (Micvotabart, RUO).pdf

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Anti-Human Fibronectin Reference Antibody (Micvotabart, RUO) (HY259066)

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