Anti-Human Fibronectin Reference Antibody (Radretumab, RUO) (HY259016)

Name: Anti-Human Fibronectin Reference Antibody (Radretumab, RUO)
Brand: abinScience
SKU: HY259016
Price: 176 USD
Availability: InStock

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Overview

Catalog No.	HY259016
Description	Radretumab (HY259016) is a research-grade recombinant antibody targeting Cold-insoluble globulin. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
Species reactivity	Human
Applications	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Host species	Human
Isotype	[(scFv-heavy-kappa)-IGHE-CH4]2
Expression system	Mammalian cells
Clonality	Monoclonal
Target	Cold-insoluble globulin, CIG, FN, Fibronectin, FN1
Endotoxin level	Please contact the lab for this information.
Purity	>95% purity as determined by SDS-PAGE.
Purification	Purified by Nickel column.
Accession	P02751
Form	Liquid
Storage buffer	0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	L19-131I, L19-SIP, 1253180-81-2
Background	Fibronectin (EDB) is a ~272 kDa protein. Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization. Participates in the regulation of type I collagen deposition by osteoblasts. Acts as a ligand for the LILRB4 receptor, inhibiting FCGR1A/CD64-mediated monocyte activation. 1. Owens, RJ. et al. (1986) The EMBO journal 5, 2825-30. PMID: 3024962 2. Garcia-Pardo, A. et al. (1987) The Biochemical journal 241, 923-8. PMID: 3593230 3. Calaycay, J. et al. (1985) The Journal of biological chemistry 260, 12136-41. PMID: 3900070 4. Rostagno, A. et al. (1994) The Journal of biological chemistry 269, 31938-45. PMID: 7989369 5. Su, MT. et al. (2021) International immunology 33, 447-458. PMID: 34089617
Note	For research use only. Not suitable for clinical or therapeutic use.

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SDS-PAGE for Research Grade Radretumab

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Datasheet

Anti-Human Fibronectin Reference Antibody (Radretumab, RUO).pdf

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Anti-Human Fibronectin Reference Antibody (Radretumab, RUO) (HY259016)

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