| Каталожный номер | HY259026 |
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| Реактивность видов | Human |
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| Применения | ELISA, Bioactivity: FACS, Functional assay, Research in vivo |
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| Хозяинский вид | Human |
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| Клоональность | Monoclonal |
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| Изотип | IgG1-hIL12, kappa |
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| ID клона | HuBC-1-hIL12 |
|---|
| Биологическая активность |
Fibronectin (FN) is a glycoprotein present in blood as well as in cells. While Fibronectin (FN) in blood has many functions, its primary role is to promote wound repair following injury [1]. Fibronectin also binds to other extracellular matrix proteins such as collagen, fibrin, and heparan sulfate proteoglycans (e.g. syndecans) [2]. |
| Система экспрессии |
Mammalian cells |
| Цель |
EDB, Cold-insoluble globulin, CIG, FN, Fibronectin, FN1 |
| Уровень эндотоксинов |
< 10 EU/mg |
| Чистота |
>95% purity as determined by SDS-PAGE. |
| Очистка |
Protein A/G purified from cell culture supernatant. |
| Номер доступа |
P02751 |
| Форма |
Liquid |
| Буфер хранения |
0.01M PBS pH 7.4 Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.
|
| Информация об использовании продукта |
| Применение |
Разбавление |
| ELISA |
1:2000-1:20000 |
|
|---|
| Устойчивость и хранение |
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| Альтернативные названия | HuBC-1ScFv, AS1409, hubc1, bc-1, bc1 |
|---|
| Фон | Fibronectin (FN) is a ~272 kDa protein. Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization. Participates in the regulation of type I collagen deposition by osteoblasts. Acts as a ligand for the LILRB4 receptor, inhibiting FCGR1A/CD64-mediated monocyte activation. _x005F_x000D_
_x005F_x000D_
1. Owens, RJ. et al. (1986) The EMBO journal 5, 2825-30. PMID: 30249622. Garcia-Pardo, A. et al. (1987) The Biochemical journal 241, 923-8. PMID: 35932303. Calaycay, J. et al. (1985) The Journal of biological chemistry 260, 12136-41. PMID: 39000704. Rostagno, A. et al. (1994) The Journal of biological chemistry 269, 31938-45. PMID: 79893695. Su, MT. et al. (2021) International immunology 33, 447-458. PMID: 34089617 |
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| Ссылки |
1. Yuan-Wan Sun, et al. Effects of E-Cigarette Aerosols with Varying Levels of Nicotine on Biomarkers of Oxidative Stress and Inflammation in Mice. Chem Res Toxicol. 2021 Apr 19;34(4):1161-1168. [HY259026]
2. Roumen Pankov, et al. Fibronectin at a glance. J Cell Sci. 2002 Oct 15;115(Pt 20):3861-3. [HY259026] |
| Примечание |
For research use only. Not suitable for clinical or therapeutic use. |
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